公开(公告)号：US11058772B2

公开(公告)日：2021-07-13

申请号：US16196537

申请日：2018-11-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor Scherz ,  Yoram Salomon ,  Arie Marcovich ,  Alexander Brandis ,  Daniel Wagner

IPC: A61K31/407 ,  A61K41/00 ,  A61K31/555 ,  A61K9/00 ,  A61K31/519 ,  A61K47/36 ,  A61N5/06

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US09938316B2

公开(公告)日：2018-04-10

申请号：US14913366

申请日：2014-08-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: C07J43/00 ,  C07J19/00

CPC classification number: C07J43/003 ,  C07J19/005

Abstract: The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

公开(公告)号：US11077128B2

公开(公告)日：2021-08-03

申请号：US16847737

申请日：2020-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: A61K31/7052 ,  C07H17/00 ,  C07J43/00 ,  A61P27/06 ,  A61P9/00 ,  C07J19/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

公开(公告)号：US10668094B2

公开(公告)日：2020-06-02

申请号：US15745441

申请日：2016-07-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: C07H17/00 ,  C07J43/00 ,  C07J19/00 ,  A61K31/7052 ,  A61P27/06 ,  A61P9/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.