The present disclosure provides a pixel arrangement structure, a display panel and a display device. The pixel arrangement structure includes a plurality of first sub-pixels, a plurality of second sub-pixels and a plurality of third sub-pixels. Each pixel includes one first sub-pixel, each second sub-pixel is shared by at least two adjacent pixels and each third sub-pixel is shared by at least two adjacent pixels. A density of the sub-pixels is 1.5 times larger than a density of the pixels in a first direction of a pixel array, and a density of the sub-pixels is 1.5 times larger than a density of the pixels in a second direction of the pixel array. The first direction is different from the second direction.