Invention Grant
- Patent Title: Binding polypeptides having a mutated scaffold
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Application No.: US14911319Application Date: 2014-08-28
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Publication No.: US09982022B2Publication Date: 2018-05-29
- Inventor: Erik Nordling , Joakim Nilsson , Patrik Strömberg
- Applicant: AFFIBODY AB
- Applicant Address: SE Solna
- Assignee: AFFIBODY AB
- Current Assignee: AFFIBODY AB
- Current Assignee Address: SE Solna
- Agency: Cantor Colburn LLP
- Priority: EP13182022 20130828
- International Application: PCT/EP2014/068259 WO 20140828
- International Announcement: WO2015/028550 WO 20150305
- Main IPC: C07K14/31
- IPC: C07K14/31 ; C07K14/00 ; C12Q1/68 ; G01N33/68 ; C07K1/04
Abstract:
The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.
Public/Granted literature
- US20160200772A1 BINDING POLYPEPTIDES HAVING A MUTATED SCAFFOLD Public/Granted day:2016-07-14
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