公开(公告)号：US09982022B2

公开(公告)日：2018-05-29

申请号：US14911319

申请日：2014-08-28

Applicant: AFFIBODY AB

Inventor： Erik Nordling ,  Joakim Nilsson ,  Patrik Strömberg

IPC: C07K14/31 ,  C07K14/00 ,  C12Q1/68 ,  G01N33/68 ,  C07K1/04

CPC classification number: C07K14/001 ,  C07K1/047 ,  C07K14/31 ,  C07K2319/00 ,  C12Q1/6874 ,  G01N33/6845

Abstract: The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

公开(公告)号：US20160200772A1

公开(公告)日：2016-07-14

申请号：US14911319

申请日：2014-08-28

Applicant: AFFIBODY AB

Inventor： Erik Nordling ,  Joakim Nilsson ,  Patrik Strömberg

IPC: C07K14/00 ,  C12Q1/68 ,  G01N33/68

CPC classification number: C07K14/001 ,  C07K1/047 ,  C07K14/31 ,  C07K2319/00 ,  C12Q1/6874 ,  G01N33/6845

Abstract: The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21 AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11 LPNLX16X17X18QX20 X21 AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

Abstract translation: 本公开涉及一类工程改造的多肽，并提供包含序列EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q（SEQ ID NO：55）的多肽。 本公开还涉及基于共同支架的多肽变体群体，包含氨基酸序列EX2X3X4AX6X7EIX10 X11LPLL16X17X18QX20X21AFIX25X26LX28X29X30PX32QSX35X36LL339E AKKLX45X46X47Q（SEQ ID NO：55）的群体中的每个多肽，以及选择具有 对来自所述群体的预定目标的亲和力。

公开(公告)号：USRE49495E1

公开(公告)日：2023-04-18

申请号：US16840882

申请日：2020-04-06

Applicant: Affibody AB

Inventor： Erik Nordling ,  Joakim Nilsson ,  Patrik Strömberg

IPC: C07K14/00 ,  C07K1/04 ,  C07K14/31 ,  C12Q1/6874 ,  G01N33/68

Abstract: The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.