- 专利标题： PDGF and VEGF aptamers having improved stability and their use in treating PDGF and VEGF mediated diseases and disorders
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申请号： US15594921申请日： 2017-05-15
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公开(公告)号： US09994857B2公开(公告)日： 2018-06-12
- 发明人: Nebojsa Janjic , Daniel W. Drolet , Amy D. Gelinas , Chi Zhang , Michael Vrkljan
- 申请人： SomaLogic, Inc.
- 申请人地址： US CO Boulder
- 专利权人： SOMALOGIC, INC.
- 当前专利权人： SOMALOGIC, INC.
- 当前专利权人地址： US CO Boulder
- 代理机构： Swanson & Bratschun, L.L.C.
- 主分类号： C12N15/115
- IPC分类号： C12N15/115
摘要：
Aptamers having improved stability against nucleases that bind PDGF and aptamers that bind VEGF are provided. In addition, aptamer constructs comprising a PDGF aptamer and a VEGF aptamer are provided. Pharmaceutical compositions comprising the aptamers and aptamer constructs are provided, as well as methods of treating conditions using the aptamers and aptamer constructs.
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