再颁专利
USRE39072E1 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
有权
2-氨基丙烷-1,3-二醇化合物,其药学用途和合成它们的中间体
- 专利标题: 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
- 专利标题(中): 2-氨基丙烷-1,3-二醇化合物,其药学用途和合成它们的中间体
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申请号: US10410387申请日: 1998-04-03
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公开(公告)号: USRE39072E1公开(公告)日: 2006-04-18
- 发明人: Kunitomo Adachi , Yoshiyuki Aoki , Tokushi Hanano , Koji Teshima , Yukio Hoshino , Tetsuro Fujita
- 申请人: Kunitomo Adachi , Yoshiyuki Aoki , Tokushi Hanano , Koji Teshima , Yukio Hoshino , Tetsuro Fujita
- 申请人地址: JP Osaka
- 专利权人: Mitsubishi Pharma Corporation
- 当前专利权人: Mitsubishi Pharma Corporation
- 当前专利权人地址: JP Osaka
- 代理机构: Crowell & Moring LLP
- 优先权: JP9-086255 19970404
- 国际申请: PCT/JP98/01571 WO 19980403
- 国际公布: WO98/45249 WO 19981015
- 主分类号: A61K31/22
- IPC分类号: A61K31/22
摘要:
The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.