公开(公告)号：US06214873B1

公开(公告)日：2001-04-10

申请号：US09402375

申请日：2000-01-05

申请人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

发明人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

IPC分类号： A61H3122

CPC分类号： C07C225/16 ,  C07C215/34 ,  C07C223/02 ,  C07F7/1804

摘要： The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

摘要翻译： 本发明涉及一般化学式R 1，R 2，R 3和R 4的化合物各自为氢或酰基，其药学上可接受的酸加成盐或其水合物; 包含该化合物的药物; 包含该化合物和药学上可接受的载体的药物组合物; 和2-氨基-2-（2-（4-（1-羟基-5-苯基戊基）苯基）乙基）丙烷-1,3-二醇或2-氨基-2-（2-（4-甲酰基苯基）乙基） 丙烷-1,3-二醇，其氨基和/或羟基被保护的两种化合物的衍生物或其盐。 本发明的化合物显示出较好的免疫抑制作用，毒性小，安全性更高，可用作预防或抑制器官​​排斥或骨髓移植的药物，或作为预防或治疗各种自身免疫性疾病或过敏性疾病的药物 疾病

公开(公告)号：USRE39072E1

公开(公告)日：2006-04-18

申请号：US10410387

申请日：1998-04-03

申请人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

发明人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

IPC分类号： A61K31/22

CPC分类号： C07C225/16 ,  C07C215/34 ,  C07C223/02 ,  C07F7/1804

摘要： The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

摘要翻译： 本发明涉及以下通式的化合物：其中R 1，R 2，R 3和R 4， 各自为氢或酰基，其药学上可接受的酸加成盐或其水合物; 包含该化合物的药物; 包含该化合物和药学上可接受的载体的药物组合物; 和2-氨基-2-（2-（4-（1-羟基-5-苯基戊基）苯基）乙基）丙烷-1,3-二醇或2-氨基-2-（2-（4-甲酰基苯基）乙基） 丙烷-1,3-二醇，其氨基和/或羟基被保护的两种化合物的衍生物或其盐。 本发明的化合物显示出较好的免疫抑制作用，毒性小，安全性更高，可用作预防或抑制器官​​排斥或骨髓移植的药物，或作为预防或治疗各种自身免疫性疾病或过敏性疾病的药物 疾病

公开(公告)号：US5068247A

公开(公告)日：1991-11-26

申请号：US549137

申请日：1990-07-05

申请人： Tetsuro Fujita ,  Takeshi Ikumoto ,  Shigeo Sasaki ,  Chiba Kenji ,  Yukio Hoshino

发明人： Tetsuro Fujita ,  Takeshi Ikumoto ,  Shigeo Sasaki ,  Chiba Kenji ,  Yukio Hoshino

IPC分类号： C07C229/22 ,  C07C229/30 ,  C07C251/40 ,  C07D307/33 ,  C07D339/06 ,  C07D409/06 ,  C07D521/00

CPC分类号： C07D307/33 ,  C07C229/22 ,  C07C229/30 ,  C07C251/40 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/06 ,  C07D409/06

摘要： There are disclosed 2-aminopentanoic acid compounds represented by the formula ##STR1## wherein R is as defined in the specification, their optical isomers, their pharmacologically acceptable salts and their use as an immunosuppressant.

公开(公告)号：US09544146B2

公开(公告)日：2017-01-10

申请号：US13143446

申请日：2010-01-21

申请人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

发明人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

IPC分类号： H04N7/18 ,  H04L9/32 ,  G06F21/32 ,  G06K9/00

CPC分类号： H04L9/3231 ,  G06F21/32 ,  G06K9/0061

摘要： Interlace noises of the image of an iris included in the image of an eye picked up through an interlaced scheme are corrected precisely within a short time. An image processing apparatus (30) corrects a digital image P based on only low-brightness pixels configuring the image of a pupil included in the digital image P of an eye. Accordingly, interlace noises included in the image of the pupil of the eye and that of the iris can be corrected precisely within a short time. Next, a checking apparatus (50) performs authentication on a subject person based on the image of the iris specified based on the corrected digital image P. Hence, precise authentication is enabled.

摘要翻译： 在短时间内精确地校正包括在通过隔行扫描方案拾取的眼睛的图像中的虹膜的图像的隔行噪声。 图像处理装置（30）仅基于配置眼睛的数字图像P中包括的瞳孔的图像的低亮度像素来校正数字图像P. 因此，可以在短时间内精确地校正包括在眼睛的瞳孔的图像和虹膜的图像中的交错噪声。 接下来，检查装置（50）基于基于经校正的数字图像P指定的光圈的图像对被摄体进行认证。因此，能够进行精确的认证。

公开(公告)号：US4831987A

公开(公告)日：1989-05-23

申请号：US89784

申请日：1987-08-27

申请人： Shinpei Nakaniwa ,  Yukio Hoshino ,  Naoki Tomisawa ,  Seiichi Otani ,  Tadashi Ariga ,  Shouji Furuhashi

发明人： Shinpei Nakaniwa ,  Yukio Hoshino ,  Naoki Tomisawa ,  Seiichi Otani ,  Tadashi Ariga ,  Shouji Furuhashi

IPC分类号： F02D41/04 ,  F02D41/10 ,  F02D41/18

CPC分类号： F02D41/182 ,  F02D41/045 ,  F02D41/10

摘要： A setting device of basic fuel injection amount for an internal combustion engine in an operating region of acceleration comparing a detected amount of intake airflow with a retrieved amount of intake airflow stored with the area of opening of a throttle valve and the engine velocity used as parameter, and when the detected amount is less than the retrieved amount, modifying the detected amount on the basis of the change ratio of opening area in the throttle valve, the engine load and the engine velocity, thereby modifying the detected amount so that it is close to the amount required by the engine.

摘要翻译： 一种内燃机的基本燃料喷射量的设定装置，其特征在于，在检测到的进气气流量与检测到的节流阀开度所存储的进气气流量相对应的加速度的运转区域和作为参数的发动机转速 并且当检测量小于检索量时，根据节气门开启面积的变化率，发动机负荷和发动机速度来修正检测量，由此修正检测量使其接近 达到发动机所需的量。

公开(公告)号：US20110280454A1

公开(公告)日：2011-11-17

申请号：US13143445

申请日：2010-01-22

申请人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

发明人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

IPC分类号： G06K9/00

CPC分类号： G06T1/00 ,  G06K9/0061

摘要： A region of an iris image where eyelash and other part images are mixed is identified with accuracy. The noise region of an iris image contained in a digital eye image (P1) where, for example, eyelash and eyelid parts are mixed is identified with accuracy based on characteristic curves obtained by scanning the iris image with arcs (AR1) and (AR2). Then, authentication is performed using data created based on the iris image from which the noise region is excluded. In this way, the subject can be authenticated with accuracy without being affected by noise.

摘要翻译： 识别睫毛和其他部位图像混合的虹膜图像的区域。 基于通过用弧（AR1）和（AR2）扫描虹膜图像获得的特征曲线，精确地识别包含在例如睫毛和眼睑部分混合的数字眼图像（P1）中的虹膜图像的噪声区域， 。 然后，使用基于从其排除噪声区域的虹膜图像创建的数据来执行认证。 以这种方式，可以准确地对被摄体进行认证，而不受噪声的影响。

公开(公告)号：US20110273554A1

公开(公告)日：2011-11-10

申请号：US13143446

申请日：2010-01-21

申请人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

发明人： Leiming Su ,  Yukio Hoshino ,  Yukio Itakura

IPC分类号： H04N7/18 ,  G06K9/40

CPC分类号： H04L9/3231 ,  G06F21/32 ,  G06K9/0061

摘要： Interlace noises of the image of an iris included in the image of an eye picked up through an interlaced scheme are corrected precisely within a short time. An image processing apparatus (30) corrects a digital image P based on only low-brightness pixels configuring the image of a pupil included in the digital image P of an eye. Accordingly, interlace noises included in the image of the pupil of the eye and that of the iris can be corrected precisely within a short time. Next, a checking apparatus (50) performs authentication on a subject person based on the image of the iris specified based on the corrected digital image P. Hence, precise authentication is enabled.

摘要翻译： 在短时间内精确地校正包括在通过隔行扫描方案拾取的眼睛的图像中的虹膜的图像的隔行噪声。 图像处理装置（30）仅基于配置眼睛的数字图像P中包括的瞳孔的图像的低亮度像素来校正数字图像P. 因此，可以在短时间内精确地校正包括在眼睛的瞳孔的图像和虹膜的图像中的交错噪声。 接下来，检查装置（50）基于基于经校正的数字图像P指定的光圈的图像对被摄体进行认证。因此，能够进行精确的认证。

公开(公告)号：US06223722B1

公开(公告)日：2001-05-01

申请号：US09379631

申请日：1999-08-24

申请人： Hirokazu Shimizu ,  Yukio Hoshino

发明人： Hirokazu Shimizu ,  Yukio Hoshino

IPC分类号： F02P3045

CPC分类号： F02D41/009 ,  F02P3/0456 ,  F02P5/15 ,  Y02T10/46

摘要： An apparatus for controlling ignition timing in an internal combustion engine includes a cam sensor for generating a standard position signal for each standard piston position, a position sensor for generating a single angle signal, a control unit for controlling ignition timing based on the standard position signal and the single angle signal, a timer for detecting a time from the standard position signal before the ignition timing, and a device for setting an ignition-starting timing after said standard position signal when an engine rotation speed is less than a predetermined rotation speed.

摘要翻译： 一种用于控制内燃机中的点火正时的装置，包括用于产生每个标准活塞位置的标准位置信号的凸轮传感器，用于产生单角度信号的位置传感器，用于基于标准位置信号控制点火正时的控制单元 单个角度信号，用于从点火正时之前的标准位置信号检测时间的定时器，以及当发动机转速小于预定转速时，在所述标准位置信号之后设定点火开始时刻的装置。

公开(公告)号：US5124331A

公开(公告)日：1992-06-23

申请号：US439044

申请日：1989-11-02

申请人： Masafumi Arita ,  Yoshitaka Fukumasu ,  Mitsuharu Sano ,  Yukio Hoshino ,  Hirotsugu Komatsu

发明人： Masafumi Arita ,  Yoshitaka Fukumasu ,  Mitsuharu Sano ,  Yukio Hoshino ,  Hirotsugu Komatsu

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： 3,4-Dihydrothieno[2,3-d]pyrimidine compounds having immunoregulating and carcinostatic actions of the general formula ##STR1## wherein A represents a C.sub.1-4 alkylene; R.sup.1 represents hydrogen, an alkyl, an aryl which may be substituted or --N(R.sup.7)(R.sup.8); R.sup.2, R.sup.3 and R.sup.4 represent hydrogen, a halogen, hydroxy, an alkyl which may be substituted by a halogen, an alkoxy, nitro, cyano or --N(R.sup.9)(R.sup.10); R.sup.5 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl or an alkoxycarbonyl; R.sup.6 represents hydrogen, a halogen, nitro, amino, cyano, an alkyl, an alkoxycarbonyl, a halogenosulfonyl or --SO.sub.2 N(R.sup.12)(R.sup.13); or R.sup.5 and R.sup.6 may, taken together, form a C.sub.3-6 alkylene chain, and their pharmaceutical use.

公开(公告)号：US4951635A

公开(公告)日：1990-08-28

申请号：US217861

申请日：1988-07-12

申请人： Shinpei Nakaniwa ,  Akihiko Araki ,  Yukio Hoshino

发明人： Shinpei Nakaniwa ,  Akihiko Araki ,  Yukio Hoshino

IPC分类号： F02D41/00 ,  F02D41/04 ,  F02D41/10

CPC分类号： F02D41/045 ,  F02D41/10

摘要： A fuel injection control system derives a correction coefficient for compensating overshooting component in measurement of an engine load indicative parameter, such as an intake air flow rate. The correction coefficient may be variable in such a manner that it increases according to increasing of the engine load. The correction coefficient may be used for correcting either the measured engine load parameter or the fuel injection amount derived taking the measured engine load.

摘要翻译： 燃料喷射控制系统导出用于补偿发动机负载指示参数（例如进气流量）的测量中的过冲分量的校正系数。 校正系数可以根据发动机负载的增加而增加。 校正系数可以用于校正所测量的发动机负载参数或者根据测量的发动机负载导出的燃料喷射量。