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    PROCESS FOR PRODUCING MELANIN, MELANIN PRODUCED BY THE PROCESS, FUNCTIONAL FILM CONTAINING THE MELANIN, AND PROCESS FOR PRODUCING THE SAME
    2.
    发明申请
    PROCESS FOR PRODUCING MELANIN, MELANIN PRODUCED BY THE PROCESS, FUNCTIONAL FILM CONTAINING THE MELANIN, AND PROCESS FOR PRODUCING THE SAME 审中-公开
    生产MELANIN的方法，由该方法生产的MELANIN，含有MELANIN的功能膜及其生产方法

    公开(公告)号：US20090317616A1

    公开(公告)日：2009-12-24

    申请号：US11995621

    申请日：2006-07-14

    申请人： Ryozo Kawai ,  Yoshiyuki Aoki ,  Eiko Aoki ,  Kyohei Takakuwa ,  Masahiko Namiki

    发明人： Ryozo Kawai ,  Yoshiyuki Aoki ,  Eiko Aoki ,  Kyohei Takakuwa ,  Masahiko Namiki

    IPC分类号： C08L29/04 ,  C04B14/00

    CPC分类号： C09B59/00 ,  C09B67/0097 ,  C09B69/104 ,  G02B5/208 ,  G02B5/3033

    摘要： The present invention provides a melanin that is excellent in coloring a functional film, and in reproducibility and stability during storage, and a method for its production. Also, the invention provides a functional film containing a melanin and its method for production. Specifically, it provides a functional film containing a melanin of which the alteration is improved and which is excellent in the property for protecting eyes from ultraviolet rays, and in its method for production.The method for producing a melanin of the present invention, comprises, at least, under controlled conditions, a step for an oxidative reaction wherein a melanin precursor is continuously oxidized while the mole ratio of the melanin precursor relative to the oxidative agent is maintained at a constant ratio, and a step for precipitation wherein a melanin is precipitated by acidifying a reaction solution after the step for an oxidative reaction.

    摘要翻译： 本发明提供了对功能性膜着色，保存时的再现性和稳定性优异的黑色素及其制造方法。 另外，本发明提供含有黑色素的功能性膜及其制造方法。 具体地说，提供了含有黑色素的功能性膜，其变化得到改善，并且在保护眼睛免受紫外线的性质方面优异，并且在其生产方法中。 本发明的黑色素的制备方法至少在受控条件下，包括氧化反应的步骤，其中黑色素前体被连续氧化，而黑色素前体相对于氧化剂的摩尔比保持在 恒定比例和沉淀步骤，其中通过在氧化反应步骤之后使反应溶液酸化而使黑色素沉淀。

    Operating device of air conditioner for vehicle
    3.
    发明授权
    Operating device of air conditioner for vehicle 有权
    车用空调机操作装置

    公开(公告)号：US07381128B2

    公开(公告)日：2008-06-03

    申请号：US10947336

    申请日：2004-09-23

    申请人： Satoshi Ogawa ,  Tomoyuki Shibata ,  Yoshiyuki Aoki

    发明人： Satoshi Ogawa ,  Tomoyuki Shibata ,  Yoshiyuki Aoki

    IPC分类号： B60H1/00 ,  G05G1/10 ,  F16H35/18

    CPC分类号： G05G1/105 ,  B60H1/0065 ,  Y10T74/2084

    摘要： A gear portion is provided on the inner peripheral surface of a dial, and a large diameter portion of a main driving gear is mated with the gear portion. A driven gear is mated with a small diameter portion of the main driving gear, and the state of an air conditioner is switched based on the moving operation of a cable through the gear portion, the main driving gear and the driven gear in the rotating operation of the dial. With this structure, it is not necessary to provide a rotary shaft as a member for transmitting an operating force to the central part or the dial. Consequently, it is possible to maintain a space in the central part of the dial. Thus, restrictions can be decreased in the case in which a knob is to be arranged.

    摘要翻译： 齿轮部设置在表盘的内周面上，主驱动齿轮的大直径部与齿轮部配合。 从动齿轮与主驱动齿轮的小直径部分配合，并且基于电缆通过齿轮部分，主驱动齿轮和从动齿轮在旋转操作中的移动操作来切换空调器的状态 的表盘。 利用这种结构，不需要将旋转轴设置为用于将操作力传递到中心部分或表盘的部件。 因此，可以在表盘的中心部分保持空间。 因此，在要布置旋钮的情况下可以减少限制。

    Piperazine compounds and medicinal use thereof
    5.
    发明申请
    Piperazine compounds and medicinal use thereof 审中-公开
    哌嗪类化合物及其医药用途

    公开(公告)号：US20060167014A1

    公开(公告)日：2006-07-27

    申请号：US11298980

    申请日：2005-12-12

    申请人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Hiroshi Morimoto ,  Masao Hisadome

    发明人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Hiroshi Morimoto ,  Masao Hisadome

    IPC分类号： A61K31/495 ,  C07D241/04

    CPC分类号： C07D239/42 ,  C07C2601/02 ,  C07D213/74 ,  C07D233/88 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52 ,  C07D239/545 ,  C07D277/42 ,  C07D295/135

    摘要： The present invention relates to a piperazine compound of the formula wherein R1 and R2 are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4 and R5 are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6 and R7 are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8 and R9 are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.

    摘要翻译： 本发明涉及下式的哌嗪化合物其中R 1和R 2各自为氢，卤素，低级烷基，低级烷氧基，氨基，取代的氨基，硝基， 羟基或氰基，R 3，R 4和R 5各自为氢，卤素，低级烷基，低级烷氧基，硝基，氨基，取代的 氨基或羟基，R 6和R 7各自为氢，低级烷基，被卤素取代的低级烷基，芳烷基，酰基或被卤素取代的低级酰基， 8和R 9各自为氢或低级烷基，Y为低级亚烷基等，环A为苯基，嘧啶基，噻唑基，吡啶基，吡唑基或咪唑基，其药学上可接受的盐 和含有这些化合物的药剂。 本发明的化合物具有优异的TNF-α产生抑制作用和/或IL-10产生促进作用，并且由于其没有或显示出仅显着降低对中枢神经系统的作用的表达，所以该化合物是有用的 作为高度安全和优越的TNF-α产生抑制剂和/或IL-10产生促进剂，并且可用作预防或治疗由异常TNF-α产生引起的各种疾病的药剂，可用IL-10固化的疾病，例如 慢性炎性疾病，急性炎性疾病，感染引起的炎性疾病，自身免疫疾病，过敏性疾病和TNF-α介导的疾病。

    2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
    6.
    再颁专利
    2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same 有权
    2-氨基丙烷-1,3-二醇化合物，其药学用途和合成它们的中间体

    公开(公告)号：USRE39072E1

    公开(公告)日：2006-04-18

    申请号：US10410387

    申请日：1998-04-03

    申请人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

    发明人： Kunitomo Adachi ,  Yoshiyuki Aoki ,  Tokushi Hanano ,  Koji Teshima ,  Yukio Hoshino ,  Tetsuro Fujita

    IPC分类号： A61K31/22

    CPC分类号： C07C225/16 ,  C07C215/34 ,  C07C223/02 ,  C07F7/1804

    摘要： The present invention relates to a compound of the general formula wherein R1, R2, R3 and R4 are each a hydrogen or an acyl, a pharmaceutically acceptable acid addition salt thereof or a hydrate thereof; a pharmaceutical comprising this compound; a pharmaceutical composition comprising this compound and a pharmaceutically acceptable carrier; and 2-amino-2-(2-(4-(1-hydroxy-5-phenylpentyl)phenyl)ethyl)propane-1,3-diol or 2-amino-2-(2-(4-formylphenyl)ethyl)propane-1,3-diol, the derivatives of the two compounds whose amino group and/or hydroxy group are(is) protected or a salt thereof. The compound of the present invention shows superior immunosuppressive action with less toxicity and higher safety, and is useful as a drug for prevention or suppression of rejection of organs or bone marrow transplantation, or as a drug for prevention or treatment of various autoimmune diseases or allergic diseases.

    摘要翻译： 本发明涉及以下通式的化合物：其中R 1，R 2，R 3和R 4， 各自为氢或酰基，其药学上可接受的酸加成盐或其水合物; 包含该化合物的药物; 包含该化合物和药学上可接受的载体的药物组合物; 和2-氨基-2-（2-（4-（1-羟基-5-苯基戊基）苯基）乙基）丙烷-1,3-二醇或2-氨基-2-（2-（4-甲酰基苯基）乙基） 丙烷-1,3-二醇，其氨基和/或羟基被保护的两种化合物的衍生物或其盐。 本发明的化合物显示出较好的免疫抑制作用，毒性小，安全性更高，可用作预防或抑制器官​​排斥或骨髓移植的药物，或作为预防或治疗各种自身免疫性疾病或过敏性疾病的药物 疾病