再颁专利
USRE41461E1 Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum
有权
来自肝炎黄杆菌的肝素酶I，II和III的纯化，组成和特异性
- 专利标题： Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum
- 专利标题（中）： 来自肝炎黄杆菌的肝素酶I，II和III的纯化，组成和特异性
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申请号： US12199157申请日： 2008-08-27
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公开(公告)号： USRE41461E1公开(公告)日： 2010-07-27
- 发明人: Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
- 申请人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
- 申请人地址： US MA Cambridge US IA Iowa City
- 专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人地址： US MA Cambridge US IA Iowa City
- 代理机构： Fish & Richardson P.C.
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12N9/00 ; C12N9/52
摘要：
A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
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