Systems and methods for converting a digital input data stream from a first sample rate to a second, fixed sample rate using a combination of hardware and software components. In one embodiment, a system includes a rate estimator configured to estimate the sample rate of an input data stream, a phase selection unit configured to select a phase for interpolation of a set of polyphase filter coefficients based on the estimated sample rate, a coefficient interpolator configured to interpolate the filter coefficients based on the selected phase, and a convolution unit configured to convolve the interpolated filter coefficients with samples of the input data stream to produce samples of a re-sampled output data stream. One or more hardware or software components are shared between multiple channels that can process data streams having independently variable sample rates.