- 专利标题： Recombinant cell clones having increased stability and methods of making and using the same
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申请号： US15203550申请日： 2016-07-06
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公开(公告)号： USRE46897E1公开(公告)日： 2018-06-19
- 发明人: Manfred Reiter , Wolfgang Mundt , Friedrich Dorner
- 申请人： Baxalta Incorporated , Baxalta GmbH
- 申请人地址： US IL Bannockburn CH Glattpark (Opfikon)
- 专利权人： Baxalta Incorporated,Baxalta GmbH
- 当前专利权人： Baxalta Incorporated,Baxalta GmbH
- 当前专利权人地址： US IL Bannockburn CH Glattpark (Opfikon)
- 代理机构： Morgan, Lewis & Bockius LLP
- 代理商 Christopher J. Betti
- 优先权： AT1073/97 19970620
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; C12N15/09 ; C12P21/00 ; C12N5/00
摘要：
Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.
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