Invention Application
WO00023414A3 SYNTHESIS OF OPTICALLY ACTIVE CYCLOHEXYLPHENYLGLYCOLIC ACID AND ITS ESTERS
审中-公开
光学活性环丙基苯乙醇酸及其酯的合成
- Patent Title: SYNTHESIS OF OPTICALLY ACTIVE CYCLOHEXYLPHENYLGLYCOLIC ACID AND ITS ESTERS
- Patent Title (中): 光学活性环丙基苯乙醇酸及其酯的合成
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Application No.: PCT/US1999/024721Application Date: 1999-10-22
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Publication No.: WO00023414A3Publication Date: 2001-12-13
- Main IPC: C07B57/00
- IPC: C07B57/00 ; C07C51/43 ; C07C51/487 ; C07C59/11 ; C07C59/54 ; C07C67/12 ; C07C69/732 ; C07C69/96 ; C07C213/06 ; C07C219/20 ; C07C229/36
Abstract:
A process for the preparation of optically active cyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.
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