发明申请
- 专利标题： AMINE DERIVATIVES
- 专利标题（中）： 作为VANILLOID受体1（VR1）拮抗剂的萘甲酰胺和萘磺酰胺衍生物
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申请号： PCT/EP2002/008493申请日： 2002-07-31
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公开(公告)号： WO2003014064A1公开(公告)日： 2003-02-20
- 发明人: YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutoma , KOKUBO, Toshio , URBAHNS, Klaus , LOWINGER, Timothy, B. , YOSHIDA, Nagahiro , FREITAG, Joachim , MEIER, Heinrich , WITTKA-NOPPER, Reilinde , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
- 申请人： BAYER AKTIENGESELLSCHAFT , YURA, Takeshi , MOGI, Muneto , IKEGAMI, Yuka , MASUDA, Tsutoma , KOKUBO, Toshio , URBAHNS, Klaus , LOWINGER, Timothy, B. , YOSHIDA, Nagahiro , FREITAG, Joachim , MEIER, Heinrich , WITTKA-NOPPER, Reilinde , MARUMO, Makiko , SHIROO, Masahiro , TAJIMI, Masaomi , TAKESHITA, Keisuke , MORIWAKI, Toshiya , TSUKIMI, Yasuhiro
- 申请人地址： 51368 Leverkusen DE
- 专利权人： BAYER AKTIENGESELLSCHAFT,YURA, Takeshi,MOGI, Muneto,IKEGAMI, Yuka,MASUDA, Tsutoma,KOKUBO, Toshio,URBAHNS, Klaus,LOWINGER, Timothy, B.,YOSHIDA, Nagahiro,FREITAG, Joachim,MEIER, Heinrich,WITTKA-NOPPER, Reilinde,MARUMO, Makiko,SHIROO, Masahiro,TAJIMI, Masaomi,TAKESHITA, Keisuke,MORIWAKI, Toshiya,TSUKIMI, Yasuhiro
- 当前专利权人： BAYER AKTIENGESELLSCHAFT,YURA, Takeshi,MOGI, Muneto,IKEGAMI, Yuka,MASUDA, Tsutoma,KOKUBO, Toshio,URBAHNS, Klaus,LOWINGER, Timothy, B.,YOSHIDA, Nagahiro,FREITAG, Joachim,MEIER, Heinrich,WITTKA-NOPPER, Reilinde,MARUMO, Makiko,SHIROO, Masahiro,TAJIMI, Masaomi,TAKESHITA, Keisuke,MORIWAKI, Toshiya,TSUKIMI, Yasuhiro
- 当前专利权人地址： 51368 Leverkusen DE
- 代理机构： BAYER AKTIENGESELLSCHAFT
- 优先权： JP232503-2001 20010731; JP392310-2001 20011225
- 主分类号： C07C235/38
- IPC分类号： C07C235/38
摘要：
An amine derivative, its tautomeric or stereoisomeric form, or a salt thereof which has vanilloid receptor 1 (VR1) antagonistic activity, is disclosed. The amine derivative has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.-
