Invention Application
- Patent Title: HIVインテグラーゼ阻害活性を有するヘテロ環化合物
- Patent Title (English): Heterocyclic compound having hiv integrase inhibitory activity
- Patent Title (中): 具有HIV整合抑制活性的杂环化合物
-
Application No.: PCT/JP2003/010212Application Date: 2003-08-11
-
Publication No.: WO2004024693A1Publication Date: 2004-03-25
- Inventor: 村井 均 , 遠藤 毅 , 黒瀬 規之 , 大司 照彦 , 吉田 弘志
- Applicant: 塩野義製薬株式会社 , 村井 均 , 遠藤 毅 , 黒瀬 規之 , 大司 照彦 , 吉田 弘志
- Applicant Address: 〒541-0045 大阪府 大阪市中央区 道修町3丁目1番8号 Osaka JP
- Assignee: 塩野義製薬株式会社,村井 均,遠藤 毅,黒瀬 規之,大司 照彦,吉田 弘志
- Current Assignee: 塩野義製薬株式会社,村井 均,遠藤 毅,黒瀬 規之,大司 照彦,吉田 弘志
- Current Assignee Address: 〒541-0045 大阪府 大阪市中央区 道修町3丁目1番8号 Osaka JP
- Agency: 山内 秀晃
- Priority: JP2002/235582 200208013; JP2002/245772 200208026; JP2003/121726 200304025; JP2003/270863 20030704
- Main IPC: C07D215/48
- IPC: C07D215/48
Abstract:
A compound having antiviral activity, specifically a heterocyclic compound having HIV integrase inhibitory activity; and a medicine containing the compound, especially an anti-HIV drug. The compound is a compound represented by the formula (I): (I) [wherein B is -C(R )= or -N=; R ' is hydrogen, etc.; one of R and R is a group represented by the formula -Z -Z -Z -R (wherein Z and Z each independently is a single bond, optionally substituted alkylene, etc.; Z is a single bond, optionally substituted alkylene, etc.; and R is optionally substituted aryl, optionally substituted heteroaryl, etc.) and the other is hydrogen; and -A - is -C(-Y)=C(-R )-C(-R )=C(-R )- (wherein Y is -OH, etc.; R is -COR (R is hydroxy, etc.), etc.; and one of R and R is carboxy, etc. and the other is hydrogen, etc.), etc.], a prodrug of the compound, a pharmaceutically acceptable salt of either, or a solvate of any of these.
Information query