Invention Application
WO2006001514A1 RSF1010 DERIVATIVE MOB-DEFICIENT PLASMID CONTAINING NO ANTIBIOTIC RESISTANCE GENE, BACTERIUM COMPRISING THE PLASMID AND METHOD FOR PRODUCING USEFUL METABOLITES
审中-公开
RSF1010含有抗生素抗性基因的衍生物MOB缺乏型PLASMID，包含PLASMID的细菌和生产有用代谢物的方法
- Patent Title: RSF1010 DERIVATIVE MOB-DEFICIENT PLASMID CONTAINING NO ANTIBIOTIC RESISTANCE GENE, BACTERIUM COMPRISING THE PLASMID AND METHOD FOR PRODUCING USEFUL METABOLITES
- Patent Title (中): RSF1010含有抗生素抗性基因的衍生物MOB缺乏型PLASMID，包含PLASMID的细菌和生产有用代谢物的方法
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Application No.: PCT/JP2005/012159Application Date: 2005-06-24
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Publication No.: WO2006001514A1Publication Date: 2006-01-05
- Inventor: KATASHKINA, Joanna, Yosifovna , SKOROKHODOVA, Aleksandra, Yurievna , ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , ERRAIS, Lopes, Lubov , BIRYUKOVA, Irina, Vladimirovna , MIRONOV, Aleksandr, Sergeevich , MASHKO, Sergei, Vladimirovich
- Applicant: AJINOMOTO CO., INC. , KATASHKINA, Joanna, Yosifovna , SKOROKHODOVA, Aleksandra, Yurievna , ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , ERRAIS, Lopes, Lubov , BIRYUKOVA, Irina, Vladimirovna , MIRONOV, Aleksandr, Sergeevich , MASHKO, Sergei, Vladimirovich
- Applicant Address: 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315 JP
- Assignee: AJINOMOTO CO., INC.,KATASHKINA, Joanna, Yosifovna,SKOROKHODOVA, Aleksandra, Yurievna,ZIMENKOV, Danila, Vadimovich,GULEVICH, Andrey, Yurievich,ERRAIS, Lopes, Lubov,BIRYUKOVA, Irina, Vladimirovna,MIRONOV, Aleksandr, Sergeevich,MASHKO, Sergei, Vladimirovich
- Current Assignee: AJINOMOTO CO., INC.,KATASHKINA, Joanna, Yosifovna,SKOROKHODOVA, Aleksandra, Yurievna,ZIMENKOV, Danila, Vadimovich,GULEVICH, Andrey, Yurievich,ERRAIS, Lopes, Lubov,BIRYUKOVA, Irina, Vladimirovna,MIRONOV, Aleksandr, Sergeevich,MASHKO, Sergei, Vladimirovich
- Current Assignee Address: 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315 JP
- Agency: KAWAGUCHI, Yoshiyuki et al.
- Priority: RU2004119027 20040624
- Main IPC: C12N15/68
- IPC: C12N15/68
Abstract:
A Mob- plasmid having a RSF1010 replicon, comprising a gene coding for Rep protein and said plasmid has been modified to inactivate gene related to mobilization ability. The present invention also describes a bacterium having an ability to produce useful metabolites, comprising the plasmid and said bacterium lack active thymidylate synthase coded by thyA gene and thymidine kinase coded by tdk gene, and a method for producing useful metabolites, such as native or recombinant proteins, enzymes, L-amino acids, nucleosides and nucleotides, organic acid, vitamins, using the bacterium.
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