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公开(公告)号：WO2005080583A2
公开(公告)日：2005-09-01
申请号：PCT/JP2005003695
申请日：2005-02-25
Applicant: AJINOMOTO KK , ZIMENKOV DANILA VADIMOVICH , GULEVICH ANDREY YURIEVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KATASHKINA JOANNA YOSIFOVNA , KIVERO ALEKSANDR DMITRIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , DOROSHENKO VERA GEORGIEVNA , MASHKO SERGEI VLADIMIROVICH
Inventor： ZIMENKOV DANILA VADIMOVICH , GULEVICH ANDREY YURIEVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KATASHKINA JOANNA YOSIFOVNA , KIVERO ALEKSANDR DMITRIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , DOROSHENKO VERA GEORGIEVNA , MASHKO SERGEI VLADIMIROVICH
CPC classification number: C12P13/22 , C12N9/18 , C12Y301/01031
Abstract: A method for producing L-amino acids, such as L-tryptophan, L-phenylalanine, and L-tyrosine, using a bacterium of the Enterobacteriaceae family is provided. The L-amino acid productivity of said bacterium is increased by enhancing an activity of 6-phosphogluconolactonase, which is encoded by the pgl gene (ybhE ORF).
Abstract translation: 提供了使用肠杆菌科的细菌生产L-氨基酸的方法，如L-色氨酸，L-苯丙氨酸和L-酪氨酸。 所述细菌的L-氨基酸生产率通过增加由pgl基因（ybhE ORF）编码的6-磷酸葡糖淀粉酶的活性而增加。
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2.发明申请METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA HAVING ENHANCED EXPRESSION OF THE GENE PCKA 审中-公开使用具有基因PCKA增强表达的细菌生产L-氨基酸的方法
公开(公告)号：WO2004090125A8
公开(公告)日：2005-06-30
申请号：PCT/JP2004004968
申请日：2004-04-06
Applicant: AJINOMOTO KK , GULEVICH ANDREY YURIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , ZIMENKOV DANILA VADIMOVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KIVERO ALEKSANDR DMITRIEVICH , BELAREVA ALLA VALENTINOVNA , MASHKO SERGEI VLADIMIROVICH
Inventor： GULEVICH ANDREY YURIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , ZIMENKOV DANILA VADIMOVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KIVERO ALEKSANDR DMITRIEVICH , BELAREVA ALLA VALENTINOVNA , MASHKO SERGEI VLADIMIROVICH
IPC: C12N15/60 , C12P13/22 , C07K14/245 , C12N9/88 , C12N15/09
CPC classification number: C12P13/22 , C12P13/227
Abstract: The present invention relates to a method for producing L-amino acids, such as L-tryptophan, L-phenylalanine and L-tyrosine, using a bacterium belonging to the genus Escherichia, and wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of PEP carboxykinase, which is coded by the pckA gene.
Abstract translation: 本发明涉及使用属于埃希氏杆菌属的细菌生产L-氨基酸如L-色氨酸，L-苯丙氨酸和L-酪氨酸的方法，其中所述细菌的L-氨基酸生产力提高 通过增强由pckA基因编码的PEP羧基激酶的活性。
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Patent Agency Ranking
公开(公告)号：WO2005080583A3
公开(公告)日：2005-09-01
申请号：PCT/JP2005/003695
申请日：2005-02-25
Applicant: AJINOMOTO CO., INC. , ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , SKOROKHODOVA, Aleksandra, Yurievna , KATASHKINA, Joanna, Yosifovna , KIVERO, Aleksandr, Dmitrievich , BIRYUKOVA, Irina, Vladimirovna , DOROSHENKO, Vera, Georgievna , MASHKO, Sergei, Vladimirovich
Inventor： ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , SKOROKHODOVA, Aleksandra, Yurievna , KATASHKINA, Joanna, Yosifovna , KIVERO, Aleksandr, Dmitrievich , BIRYUKOVA, Irina, Vladimirovna , DOROSHENKO, Vera, Georgievna , MASHKO, Sergei, Vladimirovich
IPC: C12N1/21
Abstract: A method for producing L-amino acids, such as L-tryptophan, L-phenylalanine, and L-tyrosine, using a bacterium of the Enterobacteriaceae family is provided. The L-amino acid productivity of said bacterium is increased by enhancing an activity of 6-phosphogluconolactonase, which is encoded by the pgl gene (ybhE ORF).
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4.发明申请METHOD FOR PRODUCING L-AMINO ACID USING BACTERIUM HAVING ENHANCED EXPRESSION OF PCKA GENE 审中-公开使用PCKA基因增强表达的细菌生产L-氨基酸的方法
公开(公告)号：WO2004090125A2
公开(公告)日：2004-10-21
申请号：PCT/JP2004/004968
申请日：2004-04-06
Applicant: AJINOMOTO CO. INC. , GULEVICH, Andrey, Yurievich , BIRYUKOVA, Irina, Vladimirovna , ZIMENKOV, Danila, Vadimovich , SKOROKHODOVA, Aleksandra, Yurievna , KIVERO, Aleksandr, Dmitrievich , BELAREVA, Alla, Valentinovna , MASHKO, Sergei, Vladimirovich
Inventor： GULEVICH, Andrey, Yurievich , BIRYUKOVA, Irina, Vladimirovna , ZIMENKOV, Danila, Vadimovich , SKOROKHODOVA, Aleksandra, Yurievna , KIVERO, Aleksandr, Dmitrievich , BELAREVA, Alla, Valentinovna , MASHKO, Sergei, Vladimirovich
IPC: C12N9/00
CPC classification number: C12P13/22 , C12P13/227
Abstract: The present invention relates to a method for producing L-amino acids, such as L-tryptophan, L-phenylalanine and L-tyrosine, using a bacterium belonging to the genus Escherichia, and wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of PEP carboxykinase, which is coded by the pckA gene.
Abstract translation: 本发明涉及使用属于埃希氏杆菌属的细菌生产L-氨基酸如L-色氨酸，L-苯丙氨酸和L-酪氨酸的方法，其中所述细菌的L-氨基酸生产力提高 通过增强由pckA基因编码的PEP羧基激酶的活性。
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5.发明申请RSF1010 DERIVATIVE MOB-DEFICIENT PLASMID CONTAINING NO ANTIBIOTIC RESISTANCE GENE, BACTERIUM COMPRISING THE PLASMID AND METHOD FOR PRODUCING USEFUL METABOLITES 审中-公开RSF1010含有抗生素抗性基因的衍生物MOB缺乏型PLASMID，包含PLASMID的细菌和生产有用代谢物的方法
公开(公告)号：WO2006001514A1
公开(公告)日：2006-01-05
申请号：PCT/JP2005/012159
申请日：2005-06-24
Applicant: AJINOMOTO CO., INC. , KATASHKINA, Joanna, Yosifovna , SKOROKHODOVA, Aleksandra, Yurievna , ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , ERRAIS, Lopes, Lubov , BIRYUKOVA, Irina, Vladimirovna , MIRONOV, Aleksandr, Sergeevich , MASHKO, Sergei, Vladimirovich
Inventor： KATASHKINA, Joanna, Yosifovna , SKOROKHODOVA, Aleksandra, Yurievna , ZIMENKOV, Danila, Vadimovich , GULEVICH, Andrey, Yurievich , ERRAIS, Lopes, Lubov , BIRYUKOVA, Irina, Vladimirovna , MIRONOV, Aleksandr, Sergeevich , MASHKO, Sergei, Vladimirovich
IPC: C12N15/68
Abstract: A Mob- plasmid having a RSF1010 replicon, comprising a gene coding for Rep protein and said plasmid has been modified to inactivate gene related to mobilization ability. The present invention also describes a bacterium having an ability to produce useful metabolites, comprising the plasmid and said bacterium lack active thymidylate synthase coded by thyA gene and thymidine kinase coded by tdk gene, and a method for producing useful metabolites, such as native or recombinant proteins, enzymes, L-amino acids, nucleosides and nucleotides, organic acid, vitamins, using the bacterium.
Abstract translation: 具有RSF1010复制子的Mob-质粒，其包含编码Rep蛋白的基因和所述质粒已被修饰以失活与动员能力相关的基因。 本发明还描述了具有产生有用代谢物的能力的细菌，其包含质粒和缺乏由thyA基因编码的活性胸苷酸合酶和由tdk基因编码的胸苷激酶的细菌，以及生产有用代谢物的方法，例如天然或重组 蛋白质，酶，L-氨基酸，核苷和核苷酸，有机酸，维生素，使用细菌。
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6.发明申请A METHOD FOR PRODUCING A NON-AROMATIC L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY HAVING EXPRESSION OF THE CSRA GENE ATTENUATED 审中-公开使用具有CSRA基因表达的肠杆菌属家族的细菌产生非芳香L-氨基酸的方法衰减
公开(公告)号：WO2006088231A1
公开(公告)日：2006-08-24
申请号：PCT/JP2006/303211
申请日：2006-02-16
Applicant: AJINOMOTO CO., INC. , GULEVICH, Andrey, Yurievich , ZIMENKOV, Danila, Vadimovich , KLYACHKO, Elena, Vitalievna , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich
Inventor： GULEVICH, Andrey, Yurievich , ZIMENKOV, Danila, Vadimovich , KLYACHKO, Elena, Vitalievna , LEONOVA, Tatyana, Viktorovna , KOZLOV, Yury, Ivanovich
CPC classification number: C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/24
Abstract: The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the csrA gene.
Abstract translation: 本发明提供一种使用肠杆菌科的细菌，特别是属于埃希氏杆菌属或泛菌属的细菌的非芳香族L-氨基酸的制造方法，其已被修饰以减弱csrA基因的表达。
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7.发明申请METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA HAVING ENHANCED EXPRESSION OF THE GENE PCKA 审中-公开使用具有基因PCKA增强表达的细菌生产L-氨基酸的方法
公开(公告)号：WO2004090125A3
公开(公告)日：2004-11-25
申请号：PCT/JP2004004968
申请日：2004-04-06
Applicant: AJINOMOTO KK , GULEVICH ANDREY YURIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , ZIMENKOV DANILA VADIMOVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KIVERO ALEKSANDR DMITRIEVICH , BELAREVA ALLA VALENTINOVNA , MASHKO SERGEI VLADIMIROVICH
Inventor： GULEVICH ANDREY YURIEVICH , BIRYUKOVA IRINA VLADIMIROVNA , ZIMENKOV DANILA VADIMOVICH , SKOROKHODOVA ALEKSANDRA YURIEV , KIVERO ALEKSANDR DMITRIEVICH , BELAREVA ALLA VALENTINOVNA , MASHKO SERGEI VLADIMIROVICH
IPC: C12N15/60 , C12P13/22 , C07K14/245 , C12N9/88 , C12N15/09
CPC classification number: C12P13/22 , C12P13/227
Abstract: The present invention relates to a method for producing L-amino acids, such as L-tryptophan, L-phenylalanine and L-tyrosine, using a bacterium belonging to the genus Escherichia, and wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of PEP carboxykinase, which is coded by the pckA gene.
Abstract translation: 本发明涉及使用属于埃希氏杆菌属的细菌生产L-氨基酸如L-色氨酸，L-苯丙氨酸和L-酪氨酸的方法，其中所述细菌的L-氨基酸生产力提高 通过增强由pckA基因编码的PEP羧基激酶的活性。
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