发明申请
WO2006089177A3 ISOXAZOLE COMBRETASTIN DERIVATIVES FOR THE TREATMENT OF DISORDERS
审中-公开
用于治疗疾病的异丙嗪组合物衍生物
- 专利标题： ISOXAZOLE COMBRETASTIN DERIVATIVES FOR THE TREATMENT OF DISORDERS
- 专利标题（中）： 用于治疗疾病的异丙嗪组合物衍生物
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申请号： PCT/US2006005761申请日： 2006-02-16
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公开(公告)号： WO2006089177A3公开(公告)日： 2006-12-14
- 发明人: SUN LIJUN , BORELLA CHRISTOPHER , LI HAO , JIANG JUN , CHEN SHOUJUN , KOYA KEIZO , INOUE TAKAYO , DU ZHENJIAN , FOLEY KEVIN , WU YAMING , ZHANG MEI , YING WEIWEN
- 申请人： SYNTA PHARMACEUTICALS CORP , SUN LIJUN , BORELLA CHRISTOPHER , LI HAO , JIANG JUN , CHEN SHOUJUN , KOYA KEIZO , INOUE TAKAYO , DU ZHENJIAN , FOLEY KEVIN , WU YAMING , ZHANG MEI , YING WEIWEN
- 专利权人： SYNTA PHARMACEUTICALS CORP,SUN LIJUN,BORELLA CHRISTOPHER,LI HAO,JIANG JUN,CHEN SHOUJUN,KOYA KEIZO,INOUE TAKAYO,DU ZHENJIAN,FOLEY KEVIN,WU YAMING,ZHANG MEI,YING WEIWEN
- 当前专利权人： SYNTA PHARMACEUTICALS CORP,SUN LIJUN,BORELLA CHRISTOPHER,LI HAO,JIANG JUN,CHEN SHOUJUN,KOYA KEIZO,INOUE TAKAYO,DU ZHENJIAN,FOLEY KEVIN,WU YAMING,ZHANG MEI,YING WEIWEN
- 优先权： US65389005 2005-02-17; US66011205 2005-03-08; US73391205 2005-11-04
- 主分类号： C07D261/08
- IPC分类号： C07D261/08 ; A61K31/42 ; A61P35/00 ; C07D413/04
摘要：
The invention relates to compounds of structural formula (I); or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein R a , R b , and R 2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
