Invention Application
WO2006091233A2 CELLULAR DELIVERY OF REAGENTS THAT INHIBIT GENE EXPRESSION UTILIZING THE ANTHRAX TOXIN PROTECTIVE ANTIGEN (PA)
审中-公开
细胞传播使用抗坏血酸的保护性抗原（PA）抑制基因表达的试剂
- Patent Title: CELLULAR DELIVERY OF REAGENTS THAT INHIBIT GENE EXPRESSION UTILIZING THE ANTHRAX TOXIN PROTECTIVE ANTIGEN (PA)
- Patent Title (中): 细胞传播使用抗坏血酸的保护性抗原（PA）抑制基因表达的试剂
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Application No.: PCT/US2005/025954Application Date: 2005-07-22
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Publication No.: WO2006091233A2Publication Date: 2006-08-31
- Inventor: WRIGHT, Daniel, G. , MURPHY, John, R. , ZHANG, Ying
- Applicant: BOSTON MEDICAL CENTER CORPORATION , WRIGHT, Daniel, G. , MURPHY, John, R. , ZHANG, Ying
- Applicant Address: One Boston Medical Center Place, Boston, MA 02118 US
- Assignee: BOSTON MEDICAL CENTER CORPORATION,WRIGHT, Daniel, G.,MURPHY, John, R.,ZHANG, Ying
- Current Assignee: BOSTON MEDICAL CENTER CORPORATION,WRIGHT, Daniel, G.,MURPHY, John, R.,ZHANG, Ying
- Current Assignee Address: One Boston Medical Center Place, Boston, MA 02118 US
- Agency: EISENSTEIN, Ronald, I. et al.
- Priority: US60/590,679 20040723
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
The present invention is directed to a method for delivering oligonucleotides, particularly, peptide nucleic acids (PNAs) and short interfering RNA (siRNA), into cells utilizing the Anthrax toxin protective antigen (PA). The present application also provides a method for regulating gene expression in a living cell.
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