公开(公告)号：WO2018233559A1

公开(公告)日：2018-12-27

申请号：PCT/CN2018/091455

申请日：2018-06-15

Applicant: NOVOZYMES A/S ,  ZHANG, Ying

Inventor： ZHANG, Ying ,  WANG, Yun ,  XU, Wanghui ,  ZHU, Junding

IPC: C07C31/24 ,  C07C29/09 ,  C07B63/02 ,  C12N9/24 ,  C12P19/02

CPC classification number: C07B63/02 ,  C12P19/02 ,  C12P19/14 ,  C12Y101/03

Abstract: The present invention relates to a process for increasing xylose percentage of hydrolysate of a cellulosic or hemicellulosic material, comprising: (1) hydrolyzing the cellulosic or hemicellulosic material, optionally by a first enzyme composition comprising one or more enzymes having cellulase or hemicellulase activity; and (2) purifying the material of step (1) by adding a second enzyme composition comprising one or more oxidases.

公开(公告)号：WO2018150224A1

公开(公告)日：2018-08-23

申请号：PCT/IB2017/050855

申请日：2017-02-16

Applicant: ZHANG, Ying ,  SHENZHEN RUNSHIN BIOSCIENCE

Inventor： ZHANG, Ying

IPC: C07K16/28 ,  C12N5/10 ,  A61K39/395 ,  A61P35/00

Abstract: Anti-programmed death-ligand l (PD-L1) antibodies, methods of using the same, therapeutic compositions thereof, and uses thereof in upregulating cell-mediated immune responses and treating T cell dysfunctional disorders are provided. The use of the anti-PD-L1 antibody as a diagnostic agent in vitro is also provided.

公开(公告)号：WO2014116547A1

公开(公告)日：2014-07-31

申请号：PCT/US2014/012228

申请日：2014-01-21

Applicant: CORNING INCORPORATED ,  QUESADA, Mark Alejandro ,  WANG, Jianguo ,  ZHANG, Ying

Inventor： QUESADA, Mark Alejandro ,  WANG, Jianguo ,  ZHANG, Ying

IPC: G03F7/00

CPC classification number: B05D5/00 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10S977/888

Abstract: Methods for fabricating a nanopillared substrate surface include applying a polymer solution containing an amphiphilic block copolymer and a hydrophilic homopolymer to a substrate surface. The amphiphilic block copolymer and the hydrophilic homopolymer in the polymer solution self-assemble on the substrate surface to form a self-assembled polymer layer having hydrophobic domains adjacent to the substrate surface and hydrophilic domains extending into the self-assembled polymer layer. At least a portion of the hydrophilic domains may be removed to form a plurality of pores in the exposed surface of the self-assembled polymer layer. A protective layer may be deposited on the exposed surface as a mask for etching through the plurality of pores to form through-holes. A nanopillar-forming material may be deposited onto the substrate surface via the through-holes. Then, the remaining portion of the self-assembled polymer layer may be removed to expose a nanopillared substrate surface.

Abstract translation: 用于制造纳米圆柱形基底表面的方法包括将含有两亲嵌段共聚物和亲水均聚物的聚合物溶液施加到基底表面。 聚合物溶液中的两亲性嵌段共聚物和亲水均聚物自组装在基材表面上以形成具有与基材表面相邻的疏水区域和延伸到自组装聚合物层中的亲水区域的自组装聚合物层。 亲水区域的至少一部分可以被去除以在自组装聚合物层的暴露表面中形成多个孔。 可以在暴露的表面上沉积保护层作为用于通过多个孔蚀刻的掩模以形成通孔。 可以通过通孔将纳米柱形成材料沉积到衬底表面上。 然后，可以除去自组装聚合物层的剩余部分以暴露出纳米圆柱形的衬底表面。

公开(公告)号：WO2014074406A2

公开(公告)日：2014-05-15

申请号：PCT/US2013068020

申请日：2013-11-01

Applicant: CORNING INC ,  COMSTOCK II LOVELL ELGIN II ,  GOLLIER JACQUES ,  KAZMI ABBAS MEHDI ,  ZHANG YING

Inventor： COMSTOCK II LOVELL ELGIN II ,  GOLLIER JACQUES ,  KAZMI ABBAS MEHDI ,  ZHANG YING

IPC: G06F1/16

CPC classification number: G02B5/045 ,  G06F1/1601

Abstract: Films for display device covers and display device covers comprising the same are disclosed. In one embodiment, a display cover for coupling to a display device includes a perimeter portion comprising a first surface and a second surface. A film of polymeric material may be attached to at least one of the first surface or the second surface of the perimeter portion. The film may include a first array of prisms extending from an edge of the perimeter portion to a distance L. The first array of prisms may be offset from and positioned below a surface of the film by an offset spacing dz.

Abstract translation: 公开了用于显示设备盖的膜和包括该膜的显示设备盖。 在一个实施例中，用于耦合到显示装置的显示器盖包括周边部分，该周边部分包括第一表面和第二表面。 聚合物材料膜可以附接到周边部分的第一表面或第二表面中的至少一个。 该膜可以包括从周边部分的边缘延伸到距离L的第一棱镜阵列。第一棱镜阵列可以偏移并位于膜表面下方偏移间隔dz。

公开(公告)号：WO2013082418A1

公开(公告)日：2013-06-06

申请号：PCT/US2012/067278

申请日：2012-11-30

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ZHANG, Ying ,  FENN, Percy T. ,  JOHNSON, Peter R.

Inventor： ZHANG, Ying ,  FENN, Percy T. ,  JOHNSON, Peter R.

IPC: A61K9/00 ,  A61M37/00 ,  A61K47/16 ,  A61K31/4172

CPC classification number: A61K9/0021 ,  A61K9/0087 ,  A61K31/198 ,  A61K31/4172 ,  A61K38/225 ,  A61K38/23 ,  A61K38/28 ,  A61K38/29 ,  A61K38/47 ,  A61K47/183 ,  A61K47/22 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/214 ,  A61L2300/252 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Y302/01007 ,  A61K2300/00

Abstract: A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.

Abstract translation: 公开了一种包括微针阵列和设置在微针上或其内的涂层的医疗装置和制造这种装置的方法。 该涂层包括肽治疗剂和氨基酸。 还公开了在微针阵列上用氨基酸稳定肽治疗剂的方法。 在一些情况下，肽治疗剂和氨基酸都具有净正电荷或两者具有净负电荷。 在一些情况下，肽治疗剂是组氨酸。

公开(公告)号：WO2013038279A1

公开(公告)日：2013-03-21

申请号：PCT/IB2012/054030

申请日：2012-08-07

Applicant: TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) ,  ZHANG, Ying

Inventor： ZHANG, Ying

IPC: H04L12/26

CPC classification number: H04L43/026 ,  H04L43/04 ,  H04L43/0876 ,  H04L43/12

Abstract: Flow monitoring tasks are assigned to a set of switches in a split architecture network to optimize network-wide flow monitoring. The assignment maximizes the number of monitored flows and reduces overhead of the flow monitoring. A controller receives an estimated traffic volume for each path in the network. The controller calculates, for all of the switches and all of the paths, sampling fractions that maximize the number of the flows sampled by the switches. In response to a request for setting up a new flow to traverse one of the paths in the network, the controller assigns the new flow to one of the switches that are located on the one of the paths, based on the sampling fraction for the assigned switch and the one of the paths, the bandwidth constraint and the memory constraint.

Abstract translation: 分流架构网络中的一组交换机分配了流量监控任务，以优化全网络流量监控。 分配最大化监视流量的数量，并减少流量监控的开销。 控制器接收网络中每个路径的估计交通量。 控制器为所有交换机和所有路径计算采样分数，以使由交换机采样的流量数量最大化。 响应于设置新流程以遍历网络中的一条路径的请求，控制器基于所分配的采样分数将新流量分配给位于一条路径上的交换机之一 切换和路径之一，带宽约束和内存约束。

公开(公告)号：WO2013030693A1

公开(公告)日：2013-03-07

申请号：PCT/IB2012/053920

申请日：2012-07-31

Applicant: TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) ,  KEMPF, James ,  BEHESHTI-ZAVAREH, Neda ,  ZHANG, Ying ,  NILSSON, Tord K. ,  JOHANSSON, Bengt E. ,  PETTERSSON, Sten Rune ,  LUNING, Harald

Inventor： KEMPF, James ,  BEHESHTI-ZAVAREH, Neda ,  ZHANG, Ying ,  NILSSON, Tord K. ,  JOHANSSON, Bengt E. ,  PETTERSSON, Sten Rune ,  LUNING, Harald

IPC: H04L12/911 ,  H04L12/46 ,  H04W76/02

CPC classification number: H04L47/781 ,  H04L12/4633 ,  H04L12/4666 ,  H04L47/825 ,  H04W76/12

Abstract: A method for implementing a general packet radio service (GPRS) tunnel protocol (GTP) in a packet core (PC) of a third generation (3G) network having a split architecture where a control plane of the PC of the 3G network is in a cloud computing system, the cloud computing system including a controller, the controller to execute a plurality of control plane modules, the control plane to communicate with the data plane of the PC through a control plane protocol, the data plane implemented in a plurality of network elements of the 3G network by configuring switches implementing a data plane of the SGSN and GGSN and intermediate switches to establish a first and second GTP tunnel endpoint.

Abstract translation: 一种用于在第三代（3G）网络的分组核心（PC）中实现通用分组无线电业务（GPRS）隧道协议（GTP）的方法，所述第三代（3G）网络具有分离架构，其中所述3G网络的PC的控制平面处于 云计算系统，云计算系统包括控制器，控制器执行多个控制平面模块，控制平面通过控制平面协议与PC的数据平面通信，数据平面在多个网络中实现 通过配置实现SGSN和GGSN的数据平面的交换机和中间交换机来建立第一和第二GTP隧道端点，来实现3G网络的元素。

公开(公告)号：WO2012027687A1

公开(公告)日：2012-03-01

申请号：PCT/US2011049379

申请日：2011-08-26

Applicant: 4CORNING INC 1 ,  DEROSA MICHAEL E ,  UPTON TODD M ,  ZHANG YING

Inventor： DEROSA MICHAEL E ,  UPTON TODD M ,  ZHANG YING

IPC: C08J7/02 ,  C12N5/00

CPC classification number: C08J7/02 ,  C08J2325/06 ,  C08J2365/00

Abstract: Thermoplastic polymeric sheets are rendered microporous and remain substantially flat by contacting the sheet with a first fluid composition that contains or more solvents for the polymeric sheet to render the sheet microporous and then contacting the microporous sheet with a second fluid composition that is substantially free of solvents for the polymer and that contains a non-solvent that is miscible with the one or more solvents of the first composition. Contacting the microporous sheet with the second fluid composition preferably occurs prior to substantial evaporation of the first fluid compositions, or solvents thereof, from the microporous sheet.

Abstract translation: 将热塑性聚合物片材变成微孔并且通过使片材与含有或多于聚合物片材的溶剂的第一流体组合物接触而保持基本上平坦，以使片材微孔，然后使微孔片材与基本上不含溶剂的第二流体组合物接触 并且含有与第一组合物的一种或多种溶剂混溶的非溶剂。 在微孔片与第二流体组合物接触之前，优选在第一种流体组合物或其溶剂从微孔片大量蒸发之前进行。

公开(公告)号：WO2011133637A3

公开(公告)日：2012-02-09

申请号：PCT/US2011033192

申请日：2011-04-20

Applicant: PLEXXIKON INC ,  ZHANG JIAZHONG ,  IBRAHIM PRABHA N ,  SPEVAK WAYNE ,  TSAI JAMES ,  EWING TODD ,  ZHANG YING ,  ZHANG CHAO

Inventor： ZHANG JIAZHONG ,  IBRAHIM PRABHA N ,  SPEVAK WAYNE ,  TSAI JAMES ,  EWING TODD ,  ZHANG YING ,  ZHANG CHAO

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  A61P19/00 ,  A61P25/00 ,  A61P35/00 ,  C07D487/04

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of Fms, Kit, Flt3, TrkA, TrkB and TrkC, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, global ischemia, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metasteses, gastrointestinal stromal tumors, and giant cell tumors.

Abstract translation: 其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。 在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物，其形式在Fms，Kit，Flt3，TrkA，TrkB和TrkC激酶蛋白中的一种或多种上是有活性的。 还描述了其用于治疗疾病和病症的方法，包括与Fms，Kit，Flt3，TrkA，TrkB和TrkC中的一种或多种的活性相关的疾病和病症，包括类风湿性关节炎，骨关节炎，骨质疏松症，假体周围骨质溶解， 系统性硬化症，脱髓鞘疾病，多发性硬化症，Charcot玛丽牙综合征，肌萎缩性侧索硬化症，阿尔茨海默氏病，帕金森病，全球缺血，溃疡性结肠炎，克罗恩病，免疫性血小板减少性紫癜，动脉粥样硬化，系统性红斑狼疮，自体移植骨髓造血，移植排斥 肾小球肾炎，间质性肾炎，狼疮性肾炎，肾小管坏死，糖尿病性肾病，肾肥大，I型糖尿病，急性疼痛，炎性疼痛，神经性疼痛，急性骨髓性白血病，黑素瘤，多发性骨髓瘤，乳腺癌，前列腺癌，胰腺癌，肺癌 癌症，卵巢癌，神经胶质瘤，成胶质细胞瘤，神经 纤维瘤病，溶骨性骨转移，脑转移，胃肠道间质瘤和巨细胞瘤。

公开(公告)号：WO2011054560A1

公开(公告)日：2011-05-12

申请号：PCT/EP2010/062955

申请日：2010-09-03

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM UNITED KINGDOM LIMITED ,  DORIS, Bruce ,  ZHANG, Ying ,  CHENG, Kangguo

Inventor： DORIS, Bruce ,  ZHANG, Ying ,  CHENG, Kangguo

IPC: H01L21/265 ,  H01L21/28 ,  H01L21/336

CPC classification number: H01L21/28132 ,  H01L21/26586 ,  H01L29/66787

Abstract: A method for fabrication of features of an integrated circuit and device thereof include patterning a first structure on a surface of a semiconductor device and forming spacers about a periphery of the first structure. An angled ion implantation is applied to the device such that the spacers have protected portions and unprotected portions from the angled ion implantation wherein the unprotected portions have an etch rate greater than an etch rate of the protected portions. The unprotected portions and the first structure are selectively removed with respect to the protected portions. A layer below the protected portions of the spacer is patterned to form integrated circuit features.

Abstract translation: 一种用于制造集成电路的特征的方法及其装置包括在半导体器件的表面上形成第一结构并在第一结构的周围形成间隔物。 将角度离子注入施加到器件，使得间隔物具有来自成角度离子注入的保护部分和未保护部分，其中未保护部分具有大于被保护部分的蚀刻速率的蚀刻速率。 相对于受保护部分，非保护部分和第一结构被选择性地去除。 将间隔物的受保护部分下面的层图案化以形成集成电路特征。