公开(公告)号：WO2021163451A1

公开(公告)日：2021-08-19

申请号：PCT/US2021/017818

申请日：2021-02-12

Applicant: ASKLEPIOS BIOPHARMACEUTICAL, INC.

Inventor： HOPKINS, Sam ,  ERVIN, Leigh

IPC: C12N15/86

Abstract: Disclosed herein are methods of treating a toxicity in a subject receiving recombinant viral vector, such as a recombinant adeno-associated viral AAV (rAAV) vector comprising co-administration of an antibiotic and a viral vector. In one embodiment, the antibiotic is a tetracycline or macrolide family member. Also provided herein are compositions comprising an antibiotic and a viral vector.

公开(公告)号：WO2020214650A1

公开(公告)日：2020-10-22

申请号：PCT/US2020/028229

申请日：2020-04-15

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  UNIVERSITY OF MARYLAND BALTIMORE COUNTY

Inventor： VARELAS, Xaralabos ,  STAMPOULOGLOU, Eleni ,  SZETO, Gregory

IPC: A61K31/33 ,  A61K35/17 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  C12N5/0783

Abstract: Described herein are methods for activating or differentiating a T cell comprising contacting a T cell with a pharmaceutically effective amount of an agent that inhibits Yap and culturing the T cells for a time, and under conditions sufficient to induce activation or differentiation. Compositions comprising the activated or differentiated T cells, and methods for treating a disease or disorder caused by or associated with T cell dysfunction comprising administering the same are described herein. In one embodiment, the disease or disorder is cancer, an autoimmune disease or a microbial infectious disease.

公开(公告)号：WO2020205510A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/025200

申请日：2020-03-27

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： NGO, John T. ,  WONG, Wilson ,  WONG, Nicole M. ,  LI, Hui-Shan ,  TAGUE, Elliot P.

IPC: C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N9/5

Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.

公开(公告)号：WO2020191196A1

公开(公告)日：2020-09-24

申请号：PCT/US2020/023635

申请日：2020-03-19

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： CHEN, Christopher S. ,  SUNDARAM, Subramanian ,  MICHAS, Christos ,  WHITE, Alice E. ,  BISHOP, David J.

IPC: H05K3/10 ,  B01L3/00 ,  B23H1/04

Abstract: A method for fabricating an electrode includes forming a 3D shell having a hollow interior and defining one or more openings, and directing an electrically conductive liquid through at least one of the one or more openings of the 3D shell, such that the 3D shell is at least partially filed with the electrically conductive liquid. The electrically conductive liquid can be caused to solidify within the 3D shell to form a solid electrode, or can remain a liquid to form a liquid electrode. The 3D shell can be formed having the one or more openings using a 3D printing process such as a two-photon writing system. The surface tension of the electrically conductive liquid aids in retaining the electrically conductive liquid within the 3D shell. The electrode can contact a tissue sample through one of the openings in the 3D shell.

公开(公告)号：WO2020041243A8

公开(公告)日：2020-02-27

申请号：PCT/US2019/047160

申请日：2019-08-20

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  HEALTH RESEARCH, INC.

Inventor： BEANE-EBEL, Jennifer E. ,  SPIRA, Avrum E. ,  LENBURG, Marc ,  REID, Mary E. ,  MAZZILLI, Sarah

IPC: A61B5/00 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574

Abstract: The technology described herein is directed to methods of treating and diagnosing bronchial premalignant lesions, e.g. by determining the lesion subtype using one or more biomarkers described herein.

公开(公告)号：WO2020041184A1

公开(公告)日：2020-02-27

申请号：PCT/US2019/047040

申请日：2019-08-19

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： GRINSTAFF, Mark W. ,  BEHARAJ, Anjeza

IPC: C08G64/02 ,  C09J169/00

Abstract: The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for biodegradable consumer plastics, adhesives, e.g., bioadhesives, pressure sensitive adhesives and thermos-responsive adhesives.

公开(公告)号：WO2019195731A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/026067

申请日：2019-04-05

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： ZHAO, Yanyu ,  ROBLYER, Darren

IPC: A61B5/00

Abstract: An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane.

公开(公告)号：WO2019113075A2

公开(公告)日：2019-06-13

申请号：PCT/US2018/063852

申请日：2018-12-04

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： GALAGAN, James

IPC: G01N33/74

Abstract: Described herein are methods, compositions and processes related to a microbial-based biosensor system for the detection of small molecules and analytes based on an analyte-responsive transcription factor- DNA binding mechanism with either a ratiometric fluorescent output through Förster resonance energy transfer (FRET) or a redox sensor output for the quantification of the target analyte with high sensitivity.

公开(公告)号：WO2019036403A1

公开(公告)日：2019-02-21

申请号：PCT/US2018/046597

申请日：2018-08-14

Applicant: TRUSTEES OF BOSTON UNIVERSITY ,  BOSTON MEDICAL CENTER CORPORATION

Inventor： ZHONG, Xuemei ,  WONG, Joyce

IPC: G01N33/50 ,  A61B5/05 ,  A61K9/51 ,  A61K35/14 ,  A61K35/15 ,  A61K45/06

CPC classification number: A61K35/17 ,  A61K47/24 ,  A61K47/6929 ,  A61P35/00 ,  A61P35/02 ,  B82Y5/00 ,  C07K16/00 ,  C07K16/30 ,  C07K2317/52 ,  C12N5/0635 ,  C12N5/0693 ,  C12N5/163 ,  C12N2529/00

Abstract: The technology described herein relates, at least in part, to compositions comprising and methods for isolating and enriching natural IgM-producing phagocytic B (NIMPAB) cells and methods of producing IgM antibodies using such cells, as well as uses of the antibodies produced by the methods for the prevention and treatment of diseases wherein immunotherapy with such natural IgM antibodies and their derivatives can be useful.

公开(公告)号：WO2019005528A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/038158

申请日：2018-06-19

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： KOTTON, Darrell N. ,  JACOB, Anjali

IPC: C07K14/71 ,  C12N5/00

Abstract: Described herein are methods and compositions related to induced alveolar epithelial type 2 cells (iAEC2s), e.g., artificially-produced epithelial type 2 cells.