Invention Application
WO2006138627A2 MONOCLONAL ANTIBODIES RECOGNIZING A COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEIN
审中-公开
识别凝集素阴性血清白蛋白蛋白的单克隆抗体
- Patent Title: MONOCLONAL ANTIBODIES RECOGNIZING A COAGULASE-NEGATIVE STAPHYLOCOCCAL PROTEIN
- Patent Title (中): 识别凝集素阴性血清白蛋白蛋白的单克隆抗体
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Application No.: PCT/US2006/023590Application Date: 2006-06-16
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Publication No.: WO2006138627A2Publication Date: 2006-12-28
- Inventor: PATTI, Joseph, M. , HUTCHINS, Jeff, T. , HALL, Andrea , SANTOS, Linda , HOOK, Magnus , BOWDEN, Maria
- Applicant: INHIBITEX, INC. , THE TEXAS A & M UNIVERSITY SYSTEM , PATTI, Joseph, M. , HUTCHINS, Jeff, T. , HALL, Andrea , SANTOS, Linda , HOOK, Magnus , BOWDEN, Maria
- Applicant Address: 9005 Westside Parkway, Alpharetta, Georgia 30004 US
- Assignee: INHIBITEX, INC.,THE TEXAS A & M UNIVERSITY SYSTEM,PATTI, Joseph, M.,HUTCHINS, Jeff, T.,HALL, Andrea,SANTOS, Linda,HOOK, Magnus,BOWDEN, Maria
- Current Assignee: INHIBITEX, INC.,THE TEXAS A & M UNIVERSITY SYSTEM,PATTI, Joseph, M.,HUTCHINS, Jeff, T.,HALL, Andrea,SANTOS, Linda,HOOK, Magnus,BOWDEN, Maria
- Current Assignee Address: 9005 Westside Parkway, Alpharetta, Georgia 30004 US
- Agency: SCHULMAN, B., Aaron et al.
- Priority: US60/690,940 20050616
- Main IPC: A61K39/40
- IPC: A61K39/40
Abstract:
Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis . The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
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