公开(公告)号：WO2023091251A2

公开(公告)日：2023-05-25

申请号：PCT/US2022/046383

申请日：2022-10-12

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： POLYCARPOU, Andreas, A. ,  AMIRI, Ahmad

Abstract: In an embodiment, the present disclosure pertains to a supercapacitor composed of a cathode material, a gel electrolyte, and a zinc foil anode. In some embodiments, the cathode material, the gel electrolyte, and the zinc foil anode are in a multilayered configuration. In some embodiments, the cathode and anode materials provide load-bearing capability. In an additional embodiment, the present disclosure pertains to a method of making a supercapacitor. In general, the method includes fabricating a cathode material, preparing a gel electrolyte, coating a zinc foil electrode with the gel electrolyte, and sandwiching the zinc foil electrode with the cathode material. In some embodiments, the sandwiching forms a multilayered configuration composed of the cathode material, the gel electrolyte, and the zinc foil anode. In some embodiments, the cathode and anode materials provide load-bearing capability that can include, without limitation, maximum tensile strength, Young's modulus, toughness, and combinations thereof.

公开(公告)号：WO2023086925A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/079698

申请日：2022-11-11

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： ZHAO, Feng ,  HE, Weilue

IPC: A61L27/52 ,  A61L27/36 ,  A61F2/06

Abstract: The present disclosure provides a vascular graft comprising i) one or more extracellular matrix compositions and ii) one or more hydrogels. In particular, the vascular grafts of the present disclosure can be functionalized and/or be completely biologic. The disclosure also provides methods of administering the vascular grafts as well as methods for forming the vascular grafts.

公开(公告)号：WO2023076282A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/047742

申请日：2022-10-25

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： KHAN, Mansoor ,  RAHMAN, Ziyaur ,  REDDY, Indra, K. ,  DHARANI, Satish

IPC: A61K31/33 ,  A61K31/395 ,  A61K31/55

Abstract: In an embodiment, the present disclosure pertains to a stable formulation of a primary, secondary, and/or tertiary amino group containing composition that prevents or reduces formation of a nitroso impurity until the end of stated expiration or longer, or a method of making the stable formulation of a primary, secondary, and/or tertiary amino group containing composition. In some embodiments, the composition includes a drug having a primary, secondary, and/or tertiary amino group and a pharmaceutical excipient. In some embodiments, the pharmaceutical excipient is at least one of a protective pharmaceutical excipient or a non-protective pharmaceutical excipient. In some embodiments, the composition includes an antioxidant. In some embodiments, the composition includes a chelating agent.

公开(公告)号：WO2023283363A1

公开(公告)日：2023-01-12

申请号：PCT/US2022/036395

申请日：2022-07-07

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： JAIN, Abhishek ,  TRONOLONE, James, J. ,  SAHA, Biswajit

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/04 ,  C12M1/12 ,  C12M3/04 ,  C12M3/06 ,  C12N5/00 ,  C12Q1/02

Abstract: In an embodiment, the present disclosure pertains to a medical device. In some embodiments, the medical device includes a first compartmentalized microfluidic channel flanked by two microchannels and a second compartmentalized microfluidic channel. In some embodiments, the first and second compartmentalized microfluidic channels are situated vertically one to another. In some embodiments, the medical device further includes a porous membrane situated between the first and second compartmentalized microfluidic channels. In another embodiment, the present disclosure pertains to an organ-on-chip. In some embodiments, the organ-on-chip includes a top portion having three parallel microchannels. In some embodiments, the three parallel microchannels are separated by micropillars. In some embodiments, the organ-on-chip further includes a bottom portion having a fourth microchannel and a membrane between the top portion and the bottom portion.

公开(公告)号：WO2023283317A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/036329

申请日：2022-07-07

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： BENN, Jamie, Suzanne ,  NUNEZ, Chase, M. ,  COOK, Walter, E. ,  FICHT, Allison ,  FICHT, Thomas, A. ,  CHAKI, Sankar, P.

IPC: A61K39/07

Abstract: Methods and compositions for the immunization of animals and humans using an immunization or vaccine that comprises B. anthracis Sterne strain 34F2 spores suspended in alginate in an amount sufficient to protect an animal or human from a lethal dose of anthrax.

公开(公告)号：WO2022261182A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032638

申请日：2022-06-08

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： KENT, Thomas, A. ,  DERRY, Paul, J. ,  OLSON, Kenneth, R.

IPC: A61K47/00 ,  A61K9/50 ,  A61K47/50 ,  A61K31/00

Abstract: A method of treating a Down syndrome ( DS ) subj ect with functional or at risk of decline of organ systems associated with accelerated aging due to over-production of H2S is disclosed. That method contemplates administering a pharmaceutical composition containing a H2S-reducing ef fective amount of hydrophilic polymer-substituted oxidi zed carbon nanoparticles ( OCNPs ) and an optional potentiating amount of lipoic acid or dihydrolipoic acid dissolved or dispersed in a physiologically acceptable diluent to the subj ect. The pharmaceutical composition can be administered parenterally as a liquid or per os as a solid or liquid.

公开(公告)号：WO2022256525A1

公开(公告)日：2022-12-08

申请号：PCT/US2022/031958

申请日：2022-06-02

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： KABES, Connor, Q. ,  MAXIMUCK, William, J. ,  GLADYSZ, John, A. ,  WEGENER, Aaron R.

IPC: B01J27/18 ,  B01J31/18 ,  C07C211/65 ,  C07F15/06

Abstract: In an embodiment, the present disclosure pertains to a composition having a cation and an anion. In some embodiments, a base is incorporated into the anion, and the cation and the anion form a bifunctional catalyst. In some embodiments, the cation is a chiral cobalt(III) species, and a nitrogenous Brpnsted base is incorporated into counter anions of the chiral cobalt(III) species cation. In some embodiments, the bifunctional catalyst is a tricationic cobalt(III) hydrogen bond donor catalyst, and a nitrogenous Brpnsted base is incorporated into counter anions of the tricationic cobalt(III) hydrogen bond donor catalyst. In another aspect, the present disclosure pertains to a bifuntional catalyst having a smart anion with a cationic metal species. In some embodiments, the smart anion performs a specific role in a chemical reaction without the inclusion of additional external components to accomplish a same specific role in the chemical reaction.

公开(公告)号：WO2022246310A2

公开(公告)日：2022-11-24

申请号：PCT/US2022/030486

申请日：2022-05-23

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： COTE, Gerard L. ,  MCMURRAY, Justin ,  BRANAN, Kimberly ,  NAMKOONG, Myeong ,  TIAN, Limei ,  PARK, Sung Il

IPC: A61B5/02 ,  A61B5/257 ,  A61B5/01 ,  A61B5/02108 ,  A61B5/02438 ,  A61B5/053 ,  A61B5/11 ,  G16H40/63 ,  G16H40/67 ,  G16H50/30

Abstract: Technologies for multimodal sensing include a wearable device having a flexible substrate and at least one multimodal sensor coupled to the flexible substrate. The multimodal sensor includes a photoplethysmography sensor and a bioimpedance sensor. The wearable device may include context sensors such as an accelerometer, a gyroscope, a temperature sensor, or a pressure sensor. The multimodal sensor may include an integrated pressure sensor. A processor of the wearable device is configured to receive sensor data from the photoplethysmography sensor and the bioimpedance sensor of the multimodal sensor that is indicative of a pulse curve of a user. The processor is further configured to correct the sensor data based on data received from the context sensors and to determine blood pressure data based on the corrected sensor data. The processor may be configured to store the blood pressure data or to transmit the blood pressure data to a remote computing device.

公开(公告)号：WO2022241202A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/029164

申请日：2022-05-13

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM

Inventor： HAN, Arum ,  DE FIGUEIREDO, Paul, J.

IPC: A61K47/58

Abstract: In an embodiment, the present disclosure pertains to a method for evaluation of sterility in a solution using impedance sensing. In another embodiment, the present disclosure pertains to a method for evaluation of bioburden in a solution. In a further embodiment, the present disclosure pertains to various devices for evaluation of sterility or bioburden.

公开(公告)号：WO2022182988A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017906

申请日：2022-02-25

Applicant: THE TEXAS A&M UNIVERSITY SYSTEM ,  THE METHODIST HOSPITAL SYSTEM

Inventor： BANERJEE, Debjyoti ,  LIN, C. Huie

IPC: A61M25/00 ,  A61M25/01 ,  A61B5/06

Abstract: A catheter control system may include a containment structure, a sensor coupled to the containment structure, and a plurality of actuators coupled to the containment structure. The containment structure may define a lumen configured to allow a fluid to flow therethrough, and a plurality of openings in fluid communication with the lumen. The sensor may be configured to detect a current position and/or orientation of the containment structure. Each of the actuators may be associated with at least one respective opening of the plurality of openings and configured to regulate fluid flow through the at least one respective opening.