公开(公告)号：WO2007126813A3

公开(公告)日：2009-04-30

申请号：PCT/US2007007566

申请日：2007-03-29

Applicant: INHIBITEX INC ,  UNIV ILLINOIS ,  PATTI JOSEPH M ,  HUTCHINS JEFF T ,  VERNACHIO JOHN ,  GOROVITS ELENA ,  SANTOS LINDA ,  ZHAO HONGYUAN ,  HOYER LOIS ,  ZHAO XIAOMIN

Inventor： PATTI JOSEPH M ,  HUTCHINS JEFF T ,  VERNACHIO JOHN ,  GOROVITS ELENA ,  SANTOS LINDA ,  ZHAO HONGYUAN ,  HOYER LOIS ,  ZHAO XIAOMIN

IPC: C07K1/16 ,  C12P21/08

CPC classification number: C07K16/14 ,  A61K2039/505 ,  C07K2317/76

Abstract: Monoclonal antibodies which can bind to AIs proteins from Candida albicans are provided which can be useful in the treatment and protection against infection from yeast such as Candida albicans. The monoclonal antibodies of the invention are advantageous in that they are cross-reactive and can recognize multiple proteins from the AIs family. Suitable pharmaceutical compositions, vaccines and kits based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.

Abstract translation: 提供可以结合来自白色念珠菌的AIs蛋白质的单克隆抗体，其可用于治疗和防止来自诸如白色假丝酵母等酵母的感染。 本发明的单克隆抗体的优点在于它们是交叉反应性的并且能够识别来自AIs家族的多种蛋白质。 还提供了基于本发明的单克隆抗体的合适的药物组合物，疫苗和试剂盒，以及它们的使用方法。

公开(公告)号：WO2007126813A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/007566

申请日：2007-03-29

Applicant: INHIBITEX, INC. ,  UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN ,  PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  VERNACHIO, John ,  GOROVITS, Elena ,  SANTOS, Linda ,  ZHAO, Hongyuan ,  HOYER, Lois ,  ZHAO, Xiaomin

Inventor： PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  VERNACHIO, John ,  GOROVITS, Elena ,  SANTOS, Linda ,  ZHAO, Hongyuan ,  HOYER, Lois ,  ZHAO, Xiaomin

IPC: A61K48/00

CPC classification number: C07K16/14 ,  A61K2039/505 ,  C07K2317/76

Abstract: Monoclonal antibodies which can bind to AIs proteins from Candida albicans are provided which can be useful in the treatment and protection against infection from yeast such as Candida albicans. The monoclonal antibodies of the invention are advantageous in that they are cross-reactive and can recognize multiple proteins from the AIs family. Suitable pharmaceutical compositions, vaccines and kits based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.

Abstract translation: 提供可以结合来自白色念珠菌的AIs蛋白质的单克隆抗体，其可用于治疗和防止来自诸如白色假丝酵母等酵母的感染。 本发明的单克隆抗体的优点在于它们是交叉反应性的并且能够识别来自AIs家族的多种蛋白质。 还提供了基于本发明的单克隆抗体的合适的药物组合物，疫苗和试剂盒，以及它们的使用方法。

公开(公告)号：WO2006138627A3

公开(公告)日：2007-07-12

申请号：PCT/US2006023590

申请日：2006-06-16

Applicant: INHIBITEX INC ,  TEXAS A & M UNIV SYS ,  PATTI JOSEPH M ,  HUTCHINS JEFF T ,  HALL ANDREA ,  SANTOS LINDA ,  HOEOEK MAGNUS ,  BOWDEN MARIA

Inventor： PATTI JOSEPH M ,  HUTCHINS JEFF T ,  HALL ANDREA ,  SANTOS LINDA ,  HOOK MAGNUS ,  BOWDEN MARIA

IPC: C12P21/08 ,  A61K39/395 ,  A61K39/40 ,  C12N15/74

CPC classification number: C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92

Abstract: Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis. The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.

Abstract translation: 提供可以结合表皮葡萄球菌的SdrF蛋白的单克隆抗体，其可用于治疗和保护葡萄球菌如表皮葡萄球菌感染。 本发明的单克隆抗体是有利的，除了蛋白质本身之外，它们还可以识别表皮葡萄球菌SdrF蛋白的结合结构域和亚结构域。 还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗以及它们的使用方法。

公开(公告)号：WO2006138627A2

公开(公告)日：2006-12-28

申请号：PCT/US2006/023590

申请日：2006-06-16

Applicant: INHIBITEX, INC. ,  THE TEXAS A & M UNIVERSITY SYSTEM ,  PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  HALL, Andrea ,  SANTOS, Linda ,  HOOK, Magnus ,  BOWDEN, Maria

Inventor： PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  HALL, Andrea ,  SANTOS, Linda ,  HOOK, Magnus ,  BOWDEN, Maria

IPC: A61K39/40

CPC classification number: C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92

Abstract: Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis . The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.

Abstract translation: 提供可结合表皮葡萄球菌的SdrF蛋白的单克隆抗体，其可用于治疗和保护葡萄球菌如表皮葡萄球菌感染。 本发明的单克隆抗体是有利的，除了蛋白质本身之外，它们还可以识别表皮葡萄球菌SdrF蛋白的结合结构域和亚结构域。 还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗以及它们的使用方法。