发明申请
WO2007067993A1 INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
审中-公开
HISTONE DEACETYLASE用于治疗疾病的抑制剂
- 专利标题： INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
- 专利标题（中）： HISTONE DEACETYLASE用于治疗疾病的抑制剂
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申请号： PCT/US2006/061820申请日： 2006-12-08
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公开(公告)号： WO2007067993A1公开(公告)日： 2007-06-14
- 发明人: BONNEFOUS, Celine , PAYNE, Joseph, E. , SMITH, Nicholas, D. , HOFFMAN, Timothy, Z. , SERTIC, Michael , WASH, Paul, L. , MALECHA, James, W.
- 申请人： KALYPSYS, INC. , BONNEFOUS, Celine , PAYNE, Joseph, E. , SMITH, Nicholas, D. , HOFFMAN, Timothy, Z. , SERTIC, Michael , WASH, Paul, L. , MALECHA, James, W.
- 申请人地址： 10420 WATERRIDGE CIRCLE, Sand Diego, CA 92121 US
- 专利权人： KALYPSYS, INC.,BONNEFOUS, Celine,PAYNE, Joseph, E.,SMITH, Nicholas, D.,HOFFMAN, Timothy, Z.,SERTIC, Michael,WASH, Paul, L.,MALECHA, James, W.
- 当前专利权人： KALYPSYS, INC.,BONNEFOUS, Celine,PAYNE, Joseph, E.,SMITH, Nicholas, D.,HOFFMAN, Timothy, Z.,SERTIC, Michael,WASH, Paul, L.,MALECHA, James, W.
- 当前专利权人地址： 10420 WATERRIDGE CIRCLE, Sand Diego, CA 92121 US
- 代理机构： HO, Raymond, J. et al.
- 优先权： US60/748,822 20051209; US60/748,823 20051209; US60/784,644 20060320; US60/802,823 20060522
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07C323/29 ; C07D209/08 ; C07D213/76 ; C07D231/12 ; C07D235/06 ; C07D239/26 ; C07D239/42 ; C07D271/12 ; C07D277/62 ; C07D311/14 ; C07D311/70 ; C07D401/12 ; A61P35/00
摘要：
Disclosed herein are compounds of formula I and methods used for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine- repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
