Invention Application
WO2008151211A1 SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS
审中-公开
取代的苯甲酰氨基 - 吲哚-2-羧酸及相关化合物
- Patent Title: SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS
- Patent Title (中): 取代的苯甲酰氨基 - 吲哚-2-羧酸及相关化合物
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Application No.: PCT/US2008/065711Application Date: 2008-06-04
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Publication No.: WO2008151211A1Publication Date: 2008-12-11
- Inventor: CAULFIELD, Thomas, J. , CLEMENS, Jennifer , FRANCIS, Robert S. , FREED, Brian S. , JOHN, Stanly , LE, Tieu-Binh , PEDGRIFT, Brian , RAMOS, Antonio D. , ROSSE, Gerard , SMRCINA, Martin , THORPE, David S. , WIRE, William , ZHAO, Jianhong
- Applicant: SANOFI-AVENTIS , CAULFIELD, Thomas, J. , CLEMENS, Jennifer , FRANCIS, Robert S. , FREED, Brian S. , JOHN, Stanly , LE, Tieu-Binh , PEDGRIFT, Brian , RAMOS, Antonio D. , ROSSE, Gerard , SMRCINA, Martin , THORPE, David S. , WIRE, William , ZHAO, Jianhong
- Applicant Address: 174 avenue de France F-75013 Paris FR
- Assignee: SANOFI-AVENTIS,CAULFIELD, Thomas, J.,CLEMENS, Jennifer,FRANCIS, Robert S.,FREED, Brian S.,JOHN, Stanly,LE, Tieu-Binh,PEDGRIFT, Brian,RAMOS, Antonio D.,ROSSE, Gerard,SMRCINA, Martin,THORPE, David S.,WIRE, William,ZHAO, Jianhong
- Current Assignee: SANOFI-AVENTIS,CAULFIELD, Thomas, J.,CLEMENS, Jennifer,FRANCIS, Robert S.,FREED, Brian S.,JOHN, Stanly,LE, Tieu-Binh,PEDGRIFT, Brian,RAMOS, Antonio D.,ROSSE, Gerard,SMRCINA, Martin,THORPE, David S.,WIRE, William,ZHAO, Jianhong
- Current Assignee Address: 174 avenue de France F-75013 Paris FR
- Agency: LIN, Jiang et al.
- Priority: US60/942,169 20070605
- Main IPC: C07D333/68
- IPC: C07D333/68 ; C07D333/78 ; C07C233/63 ; C07C235/54 ; C07C235/84 ; C07C311/15 ; C07C317/14 ; C07C323/62 ; A61K31/33 ; A61K31/16 ; A61P11/06 ; A61P19/02 ; A61P29/00
Abstract:
The present invention relates to A compound of the formula Ia wherein in any of its stereoisomers forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
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