Invention Application
WO2009076778A1 RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ
审中-公开
重组流感病毒表达血凝素的重组流感病毒样颗粒（VLPS）
- Patent Title: RECOMBINANT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) PRODUCED IN TRANSGENIC PLANTS EXPRESSING HEMAGGLUTININ
- Patent Title (中): 重组流感病毒表达血凝素的重组流感病毒样颗粒（VLPS）
-
Application No.: PCT/CA2009/000032Application Date: 2009-01-12
-
Publication No.: WO2009076778A1Publication Date: 2009-06-25
- Inventor: D'AOUST, Marc-André , COUTURE, Manon , ORS, Frédéric , TRÉPANIER, Sonia , LAVOIE, Pierre-Olivier , DARGIS, Michèle , VÉZINA, Louis-Philippe , LANDRY, Nathalie
- Applicant: MEDICAGO INC. , D'AOUST, Marc-André , COUTURE, Manon , ORS, Frédéric , TRÉPANIER, Sonia , LAVOIE, Pierre-Olivier , DARGIS, Michèle , VÉZINA, Louis-Philippe , LANDRY, Nathalie
- Applicant Address: 1020, route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- Assignee: MEDICAGO INC.,D'AOUST, Marc-André,COUTURE, Manon,ORS, Frédéric,TRÉPANIER, Sonia,LAVOIE, Pierre-Olivier,DARGIS, Michèle,VÉZINA, Louis-Philippe,LANDRY, Nathalie
- Current Assignee: MEDICAGO INC.,D'AOUST, Marc-André,COUTURE, Manon,ORS, Frédéric,TRÉPANIER, Sonia,LAVOIE, Pierre-Olivier,DARGIS, Michèle,VÉZINA, Louis-Philippe,LANDRY, Nathalie
- Current Assignee Address: 1020, route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- Agency: SECHLEY, Konrad A.
- Priority: CA2,615,372 20080121; US61/022,775 20080122; CAPCT/CA2008/001281 20080711; US60/990,603 20071127; US61/013,272 20071212
- Main IPC: C12N15/82
- IPC: C12N15/82 ; A01H5/00 ; A61K35/76 ; A61K39/145 ; A61P31/16 ; A61P37/04 ; C07K14/11 ; C12N7/00 ; C12N15/44 ; C12N7/01
Abstract:
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
Information query
IPC分类:
