Invention Application
- Patent Title: MASS SPECTROMETRY METHOD
- Patent Title (中): 质谱法
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Application No.: PCT/JP2011/058474Application Date: 2011-03-28
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Publication No.: WO2011122692A1Publication Date: 2011-10-06
- Inventor: NAITO, Jumpei , SATOH, Shuya , KOMATSU, Manabu , HASHIMOTO, Hiroyuki
- Applicant: CANON KABUSHIKI KAISHA , NAITO, Jumpei , SATOH, Shuya , KOMATSU, Manabu , HASHIMOTO, Hiroyuki
- Applicant Address: 30-2, Shimomaruko 3-chome, Ohta-ku, Tokyo 1468501 JP
- Assignee: CANON KABUSHIKI KAISHA,NAITO, Jumpei,SATOH, Shuya,KOMATSU, Manabu,HASHIMOTO, Hiroyuki
- Current Assignee: CANON KABUSHIKI KAISHA,NAITO, Jumpei,SATOH, Shuya,KOMATSU, Manabu,HASHIMOTO, Hiroyuki
- Current Assignee Address: 30-2, Shimomaruko 3-chome, Ohta-ku, Tokyo 1468501 JP
- Agency: OKABE, Yuzuru et al.
- Priority: JP2011-065780 20110324; JP2010-077842 20100330
- Main IPC: G01N27/62
- IPC: G01N27/62 ; G01N27/64
Abstract:
The problem to be solved by the present invention is to provide a method for treating a polypeptide including a cysteine residue for enhancing the sensitivity of detection thereof in mass spectrometry using charged particles. A mass spectrometry method for a polypeptide including a cysteine residue is provided which includes treating the polypeptide including a cysteine residue with a cyanation agent, treating the cyanated polypeptide with a base, and then desorption ionizing the base-treated polypeptides using charged particles for mass spectrometry.
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