Invention Application
WO2012093091A3 NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
审中-公开
新的酰胺类化合物及其作为抗血管生成和成骨细胞形成的抑制剂
- Patent Title: NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION
- Patent Title (中): 新的酰胺类化合物及其作为抗血管生成和成骨细胞形成的抑制剂
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Application No.: PCT/EP2012000040Application Date: 2012-01-05
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Publication No.: WO2012093091A3Publication Date: 2012-10-11
- Inventor: SCHWARTZ-ALBIEZ REINHARD , MARANO GRAZIA , FREI EVA , FRANK MARTIN , MEISTER BETINA
- Applicant: DEUTSCHES KREBSFORSCH , SCHWARTZ-ALBIEZ REINHARD , MARANO GRAZIA , FREI EVA , FRANK MARTIN , MEISTER BETINA
- Assignee: DEUTSCHES KREBSFORSCH,SCHWARTZ-ALBIEZ REINHARD,MARANO GRAZIA,FREI EVA,FRANK MARTIN,MEISTER BETINA
- Current Assignee: DEUTSCHES KREBSFORSCH,SCHWARTZ-ALBIEZ REINHARD,MARANO GRAZIA,FREI EVA,FRANK MARTIN,MEISTER BETINA
- Priority: EP11000103 2011-01-07
- Main IPC: C07H15/26
- IPC: C07H15/26 ; A61K31/7048 ; A61P35/04
Abstract:
The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell - surface. Exemplary compounds are: formulae (I), (II), (III), (IV).
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