公开(公告)号：WO2012093091A3

公开(公告)日：2012-10-11

申请号：PCT/EP2012000040

申请日：2012-01-05

Applicant: DEUTSCHES KREBSFORSCH ,  SCHWARTZ-ALBIEZ REINHARD ,  MARANO GRAZIA ,  FREI EVA ,  FRANK MARTIN ,  MEISTER BETINA

Inventor： SCHWARTZ-ALBIEZ REINHARD ,  MARANO GRAZIA ,  FREI EVA ,  FRANK MARTIN ,  MEISTER BETINA

IPC: C07H15/26 ,  A61K31/7048 ,  A61P35/04

CPC classification number: C07H15/26

Abstract: The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell - surface. Exemplary compounds are: formulae (I), (II), (III), (IV).

Abstract translation: 本发明涉及糖模拟物，其在低浓度下表现出较好的生物学活性，作为已知的糖类模拟物，通过抑制人癌细胞的粘附和/或迁移，特别是低于5mM的浓度，抑制血管生成并抑制转移的形成， 包含这些糖模拟物的药物组合物。 本发明的化合物可用作细胞表面结构的模拟物，并因此用于影响由蛋白质 - 蛋白质，糖 - 糖或糖 - 凝集素之间的键控制的细胞 - 细胞和细胞 - 细胞外（ECM）相互作用 细胞表面。 示例性化合物为：式（I），（II），（III），（IV）。

公开(公告)号：WO2012093091A2

公开(公告)日：2012-07-12

申请号：PCT/EP2012/000040

申请日：2012-01-05

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM ,  SCHWARTZ-ALBIEZ, Reinhard ,  MARANO, Grazia ,  FREI, Eva ,  FRANK, Martin ,  MEISTER, Betina

Inventor： SCHWARTZ-ALBIEZ, Reinhard ,  MARANO, Grazia ,  FREI, Eva ,  FRANK, Martin ,  MEISTER, Betina

IPC: C07H15/26 ,  A61K31/7048 ,  A61P35/04

CPC classification number: C07H15/26

Abstract: The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell-surface.

Abstract translation: 本发明涉及糖模拟物，其在低浓度下显示出较好的生物学活性，作为已知的糖类模拟物，通过抑制人癌细胞的粘附和/或迁移，特别是低于5mM的浓度，抑制血管生成并抑制转移的形成， 包含这些糖模拟物的药物组合物。 本发明的化合物可用作细胞表面结构的模拟物，并因此用于影响由蛋白质 - 蛋白质，糖 - 糖或糖 - 凝集素之间的键控制的细胞 - 细胞和细胞 - 细胞外（ECM）相互作用 细胞表面。