Invention Application
- Patent Title: BLOOD STAGE MALARIA VACCINE
- Patent Title (中): 血液疟疾疫苗
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Application No.: PCT/AU2012/000594Application Date: 2012-05-28
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Publication No.: WO2012162731A1Publication Date: 2012-12-06
- Inventor: LEE, Moses , GOOD, Michael , SPITHILL, Terry
- Applicant: GRIFFITH UNIVERSITY , La Trobe University , LEE, Moses , GOOD, Michael , SPITHILL, Terry
- Applicant Address: 170 Kessels Road Nathan, Queensland 4111 AU
- Assignee: GRIFFITH UNIVERSITY,La Trobe University,LEE, Moses,GOOD, Michael,SPITHILL, Terry
- Current Assignee: GRIFFITH UNIVERSITY,La Trobe University,LEE, Moses,GOOD, Michael,SPITHILL, Terry
- Current Assignee Address: 170 Kessels Road Nathan, Queensland 4111 AU
- Agency: FISHER ADAMS KELLY
- Priority: US61/490,761 20110527; NL2007292 20110823; US61/617,435 20120329
- Main IPC: A61K39/015
- IPC: A61K39/015 ; A61P33/06
Abstract:
An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.
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