公开(公告)号：WO2023036249A1

公开(公告)日：2023-03-16

申请号：PCT/CN2022/117838

申请日：2022-09-08

申请人： 清华大学

发明人： 张永辉 ,  李鑫 ,  蔡宁宁

IPC分类号： A61K39/015 ,  A61K39/018 ,  A61K31/675 ,  C07F9/6561 ,  A61P33/06

摘要： 提供一种包含病原体或病原体感染的宿主细胞或它们的裂解物的免疫原性组合物，其中该病原体或宿主细胞已经使用类异戊二烯代谢途径的抑制剂处理；还提供了开了使用所述的免疫原性组合物来治疗或预防由病原体感染引起的疾病或症状的方法，以及本文的免疫原性组合物在制备用于预防和/或治疗受试者中由病原体感染引起的疾病或症状的药物中的用途。

公开(公告)号：WO2023012354A1

公开(公告)日：2023-02-09

申请号：PCT/EP2022/072142

申请日：2022-08-05

申请人： INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  SORBONNE UNIVERSITE

发明人： MECHERI, Salah ,  PERONET, Roger ,  BRIQUET, Sylvie ,  SILVIE, Olivier

IPC分类号： A61K39/002 ,  C12N15/63 ,  A61K2039/545 ,  A61K2039/55527 ,  A61K2039/572 ,  A61K39/015 ,  A61P33/06

摘要： The present invention relates to recombinant Plasmodium parasites expressing IL-6 protein and their application in raising an immune response in a mammalian host against Plasmodium infection or against malaria disease, in a particular a protective response against early forms of parasite development.

公开(公告)号：WO2022251585A2

公开(公告)日：2022-12-01

申请号：PCT/US2022/031271

申请日：2022-05-27

申请人： WEINER, David ,  TURSI, Nicholas ,  PATEL, Ami

发明人： WEINER, David ,  TURSI, Nicholas ,  PATEL, Ami

IPC分类号： C07K16/20 ,  C07K14/445 ,  A61K39/395 ,  A61P33/06 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  C07K16/205 ,  C07K2317/21 ,  C07K2317/76

摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Plasmodium parasitic antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Plasmodium parasitic infection in a subject using said composition and method of generation.

公开(公告)号：WO2022236370A1

公开(公告)日：2022-11-17

申请号：PCT/AU2022/050447

申请日：2022-05-11

申请人： GRIFFITH UNIVERSITY

发明人： GOOD, Michael ,  AL-NAZAL, Hanan ,  STANISIC, Danielle

IPC分类号： A61K35/18 ,  A61K39/018 ,  A61K47/54 ,  A61K47/69 ,  A61P31/04 ,  A61P33/02 ,  A61P33/06

摘要： The present application is directed to compositions used in vaccinating mammals against erythrocytic organism infection, or treating erythrocytic infection. These compositions comprising erythrocytes and an erythrocytic organism, wherein the erythrocytes are derived from a mammalian species different to the mammalian species being administered the composition. The compositions are used to raise immune responses to infection with organisms such as Babesia sp., Anaplasma, Erlichia, Mycoplasma or Plasmodium for example, particularly Babesia sp. such as B. canis or B. divergens.

公开(公告)号：WO2022194811A1

公开(公告)日：2022-09-22

申请号：PCT/EP2022/056603

申请日：2022-03-15

申请人： SCHMIDT-WOLF, Ingo

发明人： SCHMIDT-WOLF, Ingo

IPC分类号： A61P33/06 ,  A61K35/17 ,  C12N5/0783

摘要： The present invention relates to cytokine induced Killer cells (CIKs) for use in the treatment of diseases caused by a Plasmodium infection.

公开(公告)号：WO2022109168A2

公开(公告)日：2022-05-27

申请号：PCT/US2021/059941

申请日：2021-11-18

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： TOLIA, Niraj H. ,  MA, Rui ,  DUFFY, Patrick E. ,  RENN, Jonathan P.

IPC分类号： A61K38/06 ,  A61K47/64 ,  A61K47/66 ,  A61P35/00 ,  A61P33/06 ,  A61K39/015 ,  A61K39/00 ,  A61K2039/55566 ,  A61K38/00

摘要： The disclosure provides immunogen polypeptides comprising fragments of VAR2CSA protein expressed by P. falciparum. Aspects of the disclosed immunogen polypeptides comprise all or portions of the CSA binding regions of VAR2CSA as identified by a structural study of VAR2CSA conducted by the inventors. Also provided are compositions comprising such immunogen polypeptides, and methods of using the immunogen polypeptides for vaccination and treatment of disease.

公开(公告)号：WO2022106892A1

公开(公告)日：2022-05-27

申请号：PCT/IB2021/000796

申请日：2021-11-17

申请人： INSTITUTO DE MEDICINA MOLECULAR

发明人： SETUA, Sonali ,  DIAS DA MOTA, Maria, Manuel ,  ENGUITA, Francisco, Javier ,  SUNDARAMURTHY, Varadharajan ,  RANGA-PRASAD, Harish

IPC分类号： A61K31/424 ,  A61K31/496 ,  A61P33/06

摘要： Disclosed herein are compositions and methods to prevent Plasmodium parasites from evading host cell autophagy responses, including by blocking binding of Plasmodium Upregulated in infective sporozoites 3 (UIS3) to host cell autophagy proteins, such as Microtubule-associated protein 1A/1 B-light chain 3 (LC3).

公开(公告)号：WO2022027107A1

公开(公告)日：2022-02-10

申请号：PCT/AU2021/050864

申请日：2021-08-06

申请人： MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LIMITED

发明人： BEESON, James ,  FENG, Gaoqian ,  KURTOVIC, Liriye

IPC分类号： A61K39/015 ,  A61K38/03 ,  C07K16/20 ,  A61P33/06

摘要： Immunogenic or vaccine compositions for preventing malaria, comprising or encoding CSP N-terminal (NT) sequences capable of presenting NT epitopes to a subject, and methods of administering same.

公开(公告)号：WO2021155791A1

公开(公告)日：2021-08-12

申请号：PCT/CN2021/074928

申请日：2021-02-02

申请人： MERCK SHARP & DOHME CORP. ,  THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH ,  MSD R&D (CHINA) CO., LTD. ,  DE LERA RUIZ, Manuel ,  FAVUZZA, Paola ,  GUO, Zhuyan ,  HU, Bin ,  KELLY III, Michael J. ,  LEI, Zhiyu ,  MCCAULEY, John A. ,  OLSEN, David B. ,  SLEEBS, Brad ,  TRIGLIA, Tony ,  ZHAN, Dongmei ,  ZHAO, Lianyun

发明人： DE LERA RUIZ, Manuel ,  FAVUZZA, Paola ,  GUO, Zhuyan ,  HU, Bin ,  KELLY III, Michael J. ,  LEI, Zhiyu ,  MCCAULEY, John A. ,  OLSEN, David B. ,  SLEEBS, Brad ,  TRIGLIA, Tony ,  ZHAN, Dongmei ,  ZHAO, Lianyun

IPC分类号： C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D471/04 ,  A61K31/513 ,  A61P33/06

摘要： Provided are methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. Also provided are uses of the compounds of Formula (I), as defined herein, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

公开(公告)号：WO2021146543A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/013612

申请日：2021-01-15

申请人： THE TRUSTEES OF PRINCETON UNIVERSITY ,  KIM, Hahn ,  RABINOWITZ, Joshua, D.

发明人： GHERGUROVICH, Jonathan, M.

IPC分类号： C07D239/84 ,  A61K31/517 ,  C07D239/70 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61P11/06 ,  A61P29/00 ,  A61P33/06 ,  A61P35/00 ,  A61P37/00

摘要： Provided herein are compounds having the following structural formula, wherein values for the variables are as described herein. Also provided are pharmaceutical compositions of the compounds, as well as methods of using the compounds to inhibit the oxidative pentose phosphate pathway, e.g, to treat cancer, malaria, an autoimmune disease, an inflammatory condition or asthma.