发明申请
WO2013077720A1 (R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
审中-公开
（R）-6-（二甲基氨基）-4,4- DIPHENYLHEPTAN -3-酮
- 专利标题： (R)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE
- 专利标题（中）： （R）-6-（二甲基氨基）-4,4- DIPHENYLHEPTAN -3-酮
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申请号： PCT/MY2012/000034申请日： 2012-02-28
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公开(公告)号： WO2013077720A1公开(公告)日： 2013-05-30
- 发明人: ISMAIL, Rusli , ALI, Asaraf , TAN, Soo Choon
- 申请人： UNIVERSITI SAINS MALAYSIA , ISMAIL, Rusli , ALI, Asaraf , TAN, Soo Choon
- 申请人地址： Usm Pulau Pinang, 11800 MY
- 专利权人： UNIVERSITI SAINS MALAYSIA,ISMAIL, Rusli,ALI, Asaraf,TAN, Soo Choon
- 当前专利权人： UNIVERSITI SAINS MALAYSIA,ISMAIL, Rusli,ALI, Asaraf,TAN, Soo Choon
- 当前专利权人地址： Usm Pulau Pinang, 11800 MY
- 代理机构： NANJAPPAN, Puvaneswari
- 优先权： MYPI 20111122
- 主分类号： C07C221/00
- IPC分类号： C07C221/00 ; C07C225/10 ; C07C253/30
摘要：
Methods for producing methadone and its resolution to produce ( R )-6-dimethylamino-4,4-diphenylheptan-3-one (( R )- methadone). Such methods producing first the precursor compound 4-(dimethylamino)-2,2-diphenylpentanitrile. Oxidation of 4-(dimethylamino)-2,2-diphenylpentanitrile with ethyl magnesium halide and hydrolysis with of the complex to form 6-dimethylamino-4,4-diphenylheptan-3-one. Resolution to the ( R )-isomer is effected by reaction with a bromocamphor salt. Once isolated the ( R )-isomer is crystallised.
