The fastening device with indirect firing comprises, in a housing (2), a mobile equipment (3) including a barrel (4) and a nail guide (5) so as to drive, through a piston (6) in the equipment barrel, a fastening element into a support material, driving piston propelling means and anti-firing means arranged to prevent a manual backward movement of the nail guide, which nail guide projects at rest outside the housing, Advantageously, it is mounted on the device an anti-firing lock (13) and, on the equipment (3), a locking abutment (19), the anti-firing lock being arranged for, in a resting and locking position, being on a rear abutment against said equipment locking abutment (19) and preventing the axial backward movement thereof and for, in an unlocking position, allowing the axial backward movement of the equipment.