Invention Application
WO2014019023A1 α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I
审中-公开
α7NICOTINIC乙酰胆碱受体调节剂及其用途
- Patent Title: α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I
- Patent Title (中): α7NICOTINIC乙酰胆碱受体调节剂及其用途
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Application No.: PCT/AU2013/000849Application Date: 2013-08-01
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Publication No.: WO2014019023A1Publication Date: 2014-02-06
- Inventor: HARVEY, Andrew , AVERY, Thomas , PAUL, Dharam , RIPPER, Justin , HUFF, Belinda , SINGH, Rajinder , SCHAEFFER, Laurent , JOSEPH, Christophe , MORICE, Christophe , GIETHLEN, Bruno
- Applicant: BIONOMICS LIMITED
- Applicant Address: 31 Dalgleish Street Thebarton, South Australia 5031 AU
- Assignee: BIONOMICS LIMITED
- Current Assignee: BIONOMICS LIMITED
- Current Assignee Address: 31 Dalgleish Street Thebarton, South Australia 5031 AU
- Agency: LUCAS, Mathew, A et al.
- Priority: AU2012903296 20120801; AU2013900167 20130118
- Main IPC: C07C311/37
- IPC: C07C311/37 ; C07D239/42 ; C07D239/47 ; C07D231/38 ; C07D277/42 ; C07D213/74 ; C07D241/20 ; C07D261/14 ; C07C311/08 ; C07D237/20 ; C07C311/48 ; C07C311/49 ; A61K31/18 ; A61K31/415 ; A61K31/44 ; A61K31/505 ; A61K31/664 ; A61P25/18 ; A61P25/28 ; A61P25/00 ; A61P25/22 ; A61P25/24
Abstract:
The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.
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