公开(公告)号：WO2018102885A1

公开(公告)日：2018-06-14

申请号：PCT/AU2017/051358

申请日：2017-12-08

Applicant: BIONOMICS LIMITED

Inventor： RIPPER, Justin Anthony ,  MITCHELL, Lorna Helen ,  HARVEY, Andrew John ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  FEICHTER, Nicolas ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  STAHL, Cindy

IPC: C07D487/04 ,  C07D495/04 ,  C07D491/052 ,  A61K31/4353 ,  A61K31/4375 ,  A61K31/436 ,  A61P25/28 ,  A61P25/22 ,  A61P25/24

CPC classification number: A61K45/06 ,  A61K31/4375 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  C07D471/04 ,  C07D491/052 ,  C07D495/04

Abstract: The present invention relates generally to chemical compounds and methods for their use and preparation in relation to the treatment of diseases, disorders or conditions which would benefit from the modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention thus also relates to the use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

公开(公告)号：WO2020077414A1

公开(公告)日：2020-04-23

申请号：PCT/AU2019/051137

申请日：2019-10-18

Applicant: BIONOMICS LIMITED

Inventor： MITCHELL, Lorna ,  TOOP, Hamish ,  HUFF, Belinda ,  RIPPER, Justin ,  SINGH, Rajinder ,  MORICE, Christophe ,  CONTRERAS, Jean-Marie ,  BAZZINI, Patrick ,  SCHAEFFER, Laurent ,  MICHAUT, Mathieu

IPC: C07D471/04 ,  A61P25/22 ,  A61P25/24

Abstract: The present invention relates generally to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to chemical compounds which are useful in relation to the treatment of diseases, disorders or conditions which would benefit from the modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR), such as anxiety, depression and stress related disorders.

公开(公告)号：WO2019222816A1

公开(公告)日：2019-11-28

申请号：PCT/AU2019/051013

申请日：2019-09-20

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  SINGH, Rajinder ,  SMITH, Erin ,  PAUL, Dharam ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/04 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/4166

Abstract: The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

公开(公告)号：WO2019126842A1

公开(公告)日：2019-07-04

申请号：PCT/AU2018/051409

申请日：2018-12-24

Applicant: BIONOMICS LIMITED

Inventor： HOLLIS, Courtney ,  KUCHEL, Nathan ,  SINGH, Rajinder ,  HARVEY, Andrew ,  AVERY, Thomas ,  CHERY, Florence ,  CONTRERAS, Jean-Marie ,  GAY, Julie ,  JUNG, Laetitia ,  MICHAUT-SIMON, Celine ,  MORICE, Christophe ,  STEFFEN, Alexandre

IPC: C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  A61P29/02 ,  A61K31/41 ,  A61K31/4439

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：WO2014019023A1

公开(公告)日：2014-02-06

申请号：PCT/AU2013/000849

申请日：2013-08-01

Applicant: BIONOMICS LIMITED

Inventor： HARVEY, Andrew ,  AVERY, Thomas ,  PAUL, Dharam ,  RIPPER, Justin ,  HUFF, Belinda ,  SINGH, Rajinder ,  SCHAEFFER, Laurent ,  JOSEPH, Christophe ,  MORICE, Christophe ,  GIETHLEN, Bruno

IPC: C07C311/37 ,  C07D239/42 ,  C07D239/47 ,  C07D231/38 ,  C07D277/42 ,  C07D213/74 ,  C07D241/20 ,  C07D261/14 ,  C07C311/08 ,  C07D237/20 ,  C07C311/48 ,  C07C311/49 ,  A61K31/18 ,  A61K31/415 ,  A61K31/44 ,  A61K31/505 ,  A61K31/664 ,  A61P25/18 ,  A61P25/28 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24

CPC classification number: C07C311/37 ,  C07C211/53 ,  C07C217/82 ,  C07C303/36 ,  C07C307/10 ,  C07C311/08 ,  C07C311/30 ,  C07C311/39 ,  C07C311/48 ,  C07C311/49 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/50 ,  C07D213/74 ,  C07D231/38 ,  C07D233/72 ,  C07D237/20 ,  C07D239/42 ,  C07D239/47 ,  C07D241/20 ,  C07D261/14 ,  C07D277/42 ,  C07D295/135 ,  C07D305/08 ,  C07F9/588

Abstract: The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.

Abstract translation: 本发明涉及式（I）化合物，其具有说明书中所述的取代基，其可用于α7烟碱乙酰胆碱受体（α7nAChR）的正调节。 本发明还涉及这些化合物在治疗或预防广泛范围的疾病中的用途，其中α7nAChR的阳性调节是有利的，包括神经变性和神经精神疾病以及神经性疼痛和炎性疾病。

公开(公告)号：WO2020000065A3

公开(公告)日：2020-01-02

申请号：PCT/AU2019/051194

申请日：2019-10-30

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  PAUL, Dharam ,  SINGH, Rajinder ,  SMITH, Erin ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  MICHAUT-SIMON, Celine ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61K31/497 ,  A61K31/501 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28

Abstract: The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

公开(公告)号：WO2020000065A2

公开(公告)日：2020-01-02

申请号：PCT/AU2019/051194

申请日：2019-10-30

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  PAUL, Dharam ,  SINGH, Rajinder ,  SMITH, Erin ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  MICHAUT-SIMON, Celine ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/14

Abstract: The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

公开(公告)号：WO2019218024A1

公开(公告)日：2019-11-21

申请号：PCT/AU2019/050471

申请日：2019-05-17

Applicant: BIONOMICS LIMITED

Inventor： HUFF, Belinda ,  HOLLIS, Courtney ,  TOOP, Hamish ,  KUCHEL, Nathan ,  MITCHELL, Lorna Helen ,  SINGH, Rajinder ,  AVERY, Thomas ,  MICHAUT-SIMON, Celine ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe

IPC: C07D471/04 ,  C07D231/14 ,  C07D213/81 ,  C07D213/82 ,  C07D239/28 ,  C07D239/34 ,  C07D241/24 ,  C07D249/10 ,  C07D271/10 ,  C07D277/56 ,  A61P29/00 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4965 ,  A61K31/519

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：WO2019109132A1

公开(公告)日：2019-06-13

申请号：PCT/AU2018/051258

申请日：2018-11-26

Applicant: BIONOMICS LIMITED

Inventor： RIPPER, Justin Anthony ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  FEICHTER, Nicolas ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  STAHL, Cindy

IPC: C07D261/10 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which are useful in relation to the treatment of diseases, disorders or conditions which would benefit from the modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.