公开(公告)号：WO2023059224A1

公开(公告)日：2023-04-13

申请号：PCT/RU2022/050228

申请日：2022-07-21

Applicant: JOINT STOCK COMPANY "PHARMASYNTEZ"

Inventor： KURKIN, Alexander Vital'evich ,  KAZYULKIN, Denis Nikolaevich ,  MANASOVA, Ekaterina Vladimirovna ,  LUKIANENKO, Evgenii Renol'dovich ,  BELOV, Grigorii Mihajlovich ,  IUSUPOV, Ildar Rustemovich ,  SHURYGIN, Mikhail Gennad'evich

IPC: C07D209/10 ,  C07D235/02 ,  C07D307/58 ,  C07F9/12 ,  C07F9/24 ,  C07C255/36 ,  A61K31/341 ,  A61K31/404 ,  A61K31/661 ,  A61K31/664 ,  A61P31/12

Abstract: The invention relates to new biologically active derivatives of substituted 2,3-dihydrofuran-3-ones, which can be used as antiviral agents with a broad spectrum of antiviral activity. The compound represented by Formula (I) is described: Formula (I). Also a method for treating viral disease, a method for preventing viral disease, pharmaceutical composition comprising compound according to claims 1-5 and pharmaceutically acceptable carrier and a method for obtaining of the compound of Formula (I) are described. The technical result of this invention is the development and production of new chemical compounds with high efficacy for the treatment of diseases caused by RNA viruses.

公开(公告)号：WO2022178821A1

公开(公告)日：2022-09-01

申请号：PCT/CN2021/078115

申请日：2021-02-26

Applicant: ASCENTAWITS PHARMACEUTICALS, LTD. ,  OBI PHARMA, INC.

Inventor： DUAN, Jianxin ,  MENG, Fanying ,  QI, Tianyang ,  WANG, Chun-Chung ,  CHEN, Lu-Tzu ,  LI, Wan-Fen ,  LAI, Ming-Tain

IPC: A61P35/00 ,  A61K31/04 ,  A61K31/06 ,  A61K31/664

Abstract: Provided are the use of the compound 1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-mtrophenyl)-1-ethyl-N,N'-bis(ethylene)phosphoramidate, or a pharmaceutically acceptable salt, isotopic variant or solvate thereof in the manufacture of a medicament for treating cancer, and a composition which comprises the above compound and at least one anti-cancer drug.

公开(公告)号：WO2021069686A1

公开(公告)日：2021-04-15

申请号：PCT/EP2020/078458

申请日：2020-10-09

Applicant: INSTITUT GUSTAVE ROUSSY

Inventor： PACI, Angelo ,  CHAPUT, Nathalie ,  PERFETTINI, Jean-Luc ,  DELAHOUSSE, Julia

IPC: A61K31/185 ,  A61K31/664 ,  A61K45/00 ,  A61P35/00 ,  A61P37/02 ,  A61K45/06 ,  A61K39/395 ,  C07K16/28

Abstract: The present invention relates to novel therapeutic combinations comprising an oxazaphosphorine derivative and an immune checkpoint modulator for the treatment or the prevention of cancers.

公开(公告)号：WO2021055506A1

公开(公告)日：2021-03-25

申请号：PCT/US2020/051114

申请日：2020-09-16

Applicant: CHEMIC LABORATORIES, INC.

Inventor： JONES, Gerald S., Jr. ,  ST. LAURENT, Joseph P. ,  GOODRICH, Scott A.

IPC: A61K31/34 ,  A61K31/345 ,  A61K31/664 ,  A61P31/04 ,  C07D307/34 ,  C07D307/36

Abstract: Described herein are compounds that act as antimicrobial agents, compositions comprising these compounds, and methods of their use in to treating infections caused by Helicobacter pylori (H. pylori) or killing or inhibititing the growth of H. pylori.

公开(公告)号：WO2020121122A1

公开(公告)日：2020-06-18

申请号：PCT/IB2019/060430

申请日：2019-12-04

Applicant: JANSSEN BIOPHARMA, INC.

Inventor： ZHONG, Minghong ,  WANG, Guangyi

IPC: C07D239/47 ,  C07D239/54 ,  C07D473/18 ,  C07D473/34 ,  C07D487/04 ,  C07F9/09 ,  C07F9/24 ,  A61P31/12 ,  A61P31/20 ,  A61K31/513 ,  A61K31/52 ,  A61K31/522 ,  A61K31/6615 ,  A61K31/664 ,  A61K31/685

Abstract: Described herein are cyclobutyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclobutyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV.

公开(公告)号：WO2019203497A1

公开(公告)日：2019-10-24

申请号：PCT/KR2019/004349

申请日：2019-04-11

Applicant: 국립암센터 ,  주식회사 유틸렉스

Inventor： 최범규 ,  김선희 ,  권병세 ,  김영호

IPC: A61K39/395 ,  A61K31/664 ,  A61K31/7076 ,  A61P35/00

Abstract: 본 발명은 고갈성 항 CD4 단일클론항체를 포함하는 항암 T 세포 치료제 보조용 조성물 및 이의 용도에 대한 것이다. 따라서, 본 발명의 고갈성 항 CD4 단일클론항체(depleting anti-CD4 monoclonal antibody)를 포함하는 조성물의 경우 면역결핍상태를 유지함으로써 암항원 특이적 항암 T 세포 치료제의 항암효과를 극대화할 수 있으므로 효과적이다. 또한 상기 조성물을 5일 내지 8일 간격으로 2회 이상 투여되는 경우 효과가 더욱 우수하다.

公开(公告)号：WO2019152536A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/015875

申请日：2019-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： JUNG, Michael, E. ,  CHEN, Xiaohong ,  WANG, Cun-Yu ,  LI, Jiong ,  ZHENG, Jie

IPC: C07C233/32 ,  C07C233/33 ,  C07C233/62 ,  C07C233/76 ,  C07C311/07 ,  C07D213/68 ,  C07D213/89 ,  C07D213/26 ,  C07D295/145 ,  C07D295/10 ,  C07D279/12 ,  C07D401/12 ,  C07D401/06 ,  C07D413/06 ,  C07D413/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07F9/44 ,  A61K31/45 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4436 ,  A61K31/164 ,  A61K31/18 ,  A61K31/664 ,  A61P35/00

Abstract: The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.

公开(公告)号：WO2019051489A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/050471

申请日：2018-09-11

Applicant: SPEROVIE BIOSCIENCES, INC.

Inventor： IYER, Radhakrishnan, P.

IPC: A61K31/664 ,  A61K31/675 ,  A61P1/16

Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.

公开(公告)号：WO2019032749A3

公开(公告)日：2019-02-14

申请号：PCT/US2018/045874

申请日：2018-08-08

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES ,  WILSON, Samuel, H. ,  BEARD, William, A. ,  SHOCK, David, D.

Inventor： WILSON, Samuel, H. ,  BEARD, William, A. ,  SHOCK, David, D.

IPC: A61K31/664 ,  A61P31/18

Abstract: The description provides compositions and methods of using a pyrophosphate analog, in which the bridging oxygen is replaced with an imido group (PNP) to increase the rate of the reverse polymerase reaction.

公开(公告)号：WO2019017814A1

公开(公告)日：2019-01-24

申请号：PCT/RU2018/000126

申请日：2018-03-02

Applicant: ИВАЩЕНКО, Александр Васильевич ,  ИВАЩЕНКО, Андрей Александрович ,  САВЧУК, Николай Филиппович ,  ИВАЩЕНКО, Алена Александровна ,  АЛЛА ХЕМ, ЛЛС

Inventor： ИВАЩЕНКО, Александр Васильевич ,  ИВАЩЕНКО, Андрей Александрович ,  САВЧУК, Николай Филиппович ,  РОГОВОЙ, Борис ,  БЫЧКО, Вадим Васильевич

IPC: C07D311/43 ,  C07D401/12 ,  C07D403/12 ,  C07D411/04 ,  C07F9/22 ,  A61K31/4025 ,  A61K31/454 ,  A61K31/55 ,  A61K31/506 ,  A61K31/664 ,  A61K31/20

CPC classification number: A61K31/4025 ,  A61K31/454 ,  A61K31/506 ,  A61K31/55 ,  A61K31/664 ,  A61P31/20 ,  C07C311/43 ,  C07D401/12 ,  C07D403/12 ,  C07D411/04 ,  C07F9/22

Abstract: Настоящее изобретение относится к новым ингибиторам вируса гепатита В (ВГВ, HBV) в качестве химиотерапевтических средств для лечения ВГВ. Эти соединения связываются с кор-антигеном ВГВ и вызывают формирование аберрантных вирусных капсид, не несущих вирусный геном, что приводит к образованию и секреции дефектных (невирулентных) вирусных частиц. Ингибитор ВГВ, представляющий собой соединение общей формулы 1 и формулы 2, его изотопно-обогащенный аналог, фармацевтически приемлемую соль, гидрат, сольват, кристаллическую или поликристаллическую форму, где R представляет собой водород или метил; n=1, 2 или 3.