Invention Application
WO2015127158A1 METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC MODULATION OF TARGET ANTIGENS
审中-公开
方法，组合物和用于细胞特异性调节靶抗原的试剂盒
- Patent Title: METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC MODULATION OF TARGET ANTIGENS
- Patent Title (中): 方法，组合物和用于细胞特异性调节靶抗原的试剂盒
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Application No.: PCT/US2015/016737Application Date: 2015-02-20
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Publication No.: WO2015127158A1Publication Date: 2015-08-27
- Inventor: GROMADA, Jesper , SMITH, Eric , MURPHY, Andrew , PAPADOPOULOS, Nicholas , MARTIN, Joel , YANCOPOULOS, George , MACDONALD, Douglas , BUCKLER, David
- Applicant: REGENERON PHARMACEUTICALS, INC.
- Applicant Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Agency: ZAHNER, Joseph
- Priority: US61/942,791 20140221
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/02 ; C07K16/30
Abstract:
The present invention provides, inter alia, a method for cell-specific modulation of a target antigen. The method comprises contacting a target cell having the target antigen on the surface of the target cell with: (a) first multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigen binding domain (T1); and (b) a second multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen binding domain (T2); wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceutical compositions and kits thereof are also included in the present invention.
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