公开(公告)号：WO2022086854A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/055415

申请日：2021-10-18

Applicant: CAMAS INCORPORATED

Inventor： MITTENESS, Bradley M. ,  SIMPLOT, Scott ,  HAWKINS, Michelle L. ,  ROBLEY, Brian ,  LARSON, Philip ,  HULL, Jason

IPC: A61P11/00 ,  A61P31/14 ,  A61P31/16 ,  C07K14/08 ,  C07K14/165 ,  C07K14/175 ,  C07K14/18 ,  C07K16/02 ,  C07K16/10 ,  C07K16/12 ,  C12N15/40 ,  C12N15/44 ,  C12N15/50 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/215

Abstract: Egg laying birds on egg farms are inoculated with one or more disease antigens from microbial organisms causing infectious diseases. Egg material from the eggs contain one or more avian antibodies against the microbial organisms and these avian antibodies can specifically bind and/or neutralize the microbial organisms upon consumption by individuals in a population. Egg products comprising the one or more avian antibodies are provided to individuals in the population to increase the prevalence of avian antibodies against the microbial organism in the population. The egg products are provided in a variety of formulations for protecting individuals against the disease and/or for reducing the susceptibility for acquiring the disease. Egg products effective against infections of SARS-CoV-2 in individuals and for reducing the incidence of Covid-19 are provided. Methods are provided to decrease the infection rates of infectious diseases in a population of individuals.

公开(公告)号：WO2021100993A1

公开(公告)日：2021-05-27

申请号：PCT/KR2020/006080

申请日：2020-05-08

Applicant: (주)애드바이오텍

Inventor： 정홍걸 ,  백두연 ,  원미경

IPC: C07K16/28 ,  C07K16/02 ,  A61P3/04 ,  A61K39/00

Abstract: 본 발명은 NPC1L1(Niemann-Pick C1-Like1) 재조합 단백질을 이용하여 제조된 항원을 닭과 이종인 동물에 접종하여 이종항체를 제조한 다음, 상기 항원 및 이종항체를 결합시킨 복합체를 산란계에 접종함으로써 난황항체를 제조하는 콜레스테롤 흡수 억제를 통한 비만 예방 또는 치료용 난황항체의 제조방법에 관한 것이다. 본 발명에 따르면, 콜레스테롤 흡수 억제를 통한 비만 예방 또는 치료용 난황항체의 제조방법은 항원-이종항체 복합체를 산란계에 주입함으로써 난황항체를 대량으로 제조 및 생산할 수 있으며, 이에 따라 제조된 난황항체의 경우, NPC1L1(Niemann-Pick C1-Like1) 재조합 단백질에 대한 특이성 및 결합성이 높아 NPC1L1 단백질의 역할을 차단시킴으로써 장 내에서의 콜레스테롤 흡수를 억제하고, 결론적으로는 비만을 예방 또는 치료할 수 있다.

公开(公告)号：WO2021087441A2

公开(公告)日：2021-05-06

申请号：PCT/US2020/058502

申请日：2020-11-02

Applicant: ANUBIS BIO CORPORATION

Inventor： SCHULTZ, Thomas, A.

IPC: A61K39/395 ,  A61K39/12 ,  A61K49/16 ,  C07K16/08 ,  C07K16/06 ,  C07K16/02 ,  A61K2039/505 ,  A61K2039/542 ,  A61K39/40 ,  A61K39/42 ,  C07K16/081 ,  C07K16/1232 ,  C07K16/1235 ,  C07K2317/12 ,  C07K2317/23

Abstract: A composition for treatment of African Swine Fever in swine includes avian-sourced antibodies specific for an African Swine Fever Virus isolate. These antibodies are produced by avian animals immunized against the African Swine Fever Virus isolate and mixed with a protective/reactive matrix obtained from, isolated from, or derived from, non-hyperimmune colostrum.

公开(公告)号：WO2016114677A1

公开(公告)日：2016-07-21

申请号：PCT/RO2015/000019

申请日：2015-07-21

Applicant: ROMVAC COMPANY SA

Inventor： PATRASCU, Ionel, Victor ,  CHIURCIU, Viorica ,  CHIURCIU, Constantin ,  MIHAI, Iiuliana ,  TOPILESCU, Georgiana

IPC: C07K16/02 ,  C07K16/08 ,  C07K16/12

CPC classification number: C07K16/02 ,  C07K16/087 ,  C07K16/1214 ,  C07K16/1217 ,  C07K16/1228 ,  C07K16/1232 ,  C07K16/1235 ,  C07K16/1242 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1282 ,  C07K2317/23

Abstract: This invention refers to the manufacturing method of the hyperimmune egg-PC2 consisting of preparation of antigens and immunization of laying chickens with a mixture of antigens prepared from human- and animal-pathogenic germs. This invention refers to the composition of antigens prepared from a mixture of antibiotic-resistant strains from a single bacterial species and from a mixture of various species of bacteria, viruses and fungi, all representing a stimulus administered in each chicken.

Abstract translation: 本发明涉及由抗原制备和由人和动物致病菌制备的抗原混合物产蛋鸡免疫的超免疫卵PC2的制造方法。 本发明涉及由来自单一菌种的抗生素抗性菌株和各种细菌，病毒和真菌的混合物的混合物制备的抗原的组合物，所有这些都表示在每只鸡中施用的刺激物。

公开(公告)号：WO2015083375A1

公开(公告)日：2015-06-11

申请号：PCT/JP2014/006028

申请日：2014-12-02

Applicant: オーストリッチファーマ株式会社

Inventor： 塚本　康浩

IPC: C07K16/02 ,  A61K8/64 ,  A61K8/98 ,  A61K39/395 ,  A61P17/14 ,  A61Q7/00 ,  C07K16/26 ,  C07K16/40

CPC classification number: C07K16/40 ,  A61K8/64 ,  A61K8/98 ,  A61K39/3955 ,  A61K39/39583 ,  A61Q5/02 ,  A61Q7/00 ,  C07K16/02 ,  C07K16/26 ,  C07K16/44 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/76 ,  C12N9/001 ,  C12Y103/01022

Abstract: 　抜け毛の原因は、不明な点が多く完全に解明されているわけではない。しかし、５α－リダクターゼがＤＨＴホルモンを活性化させ、それによって頭皮の男性ホルモンの活性が活発化するために、毛根部の細胞の活性が失われることが原因の一因と考えられている。　本発明は、５α－リダクターゼ若しくはＤＨＴを抗原として鳥類の雌に接種 させそこから得た抗体を頭皮に与えることで、ＤＨＴの活性を抑制し、毛根部の細胞活性を高めるものである。この抗体は、他の成分と共に、組成物として利用することができ、例えば他の育毛促進剤と一緒に育毛剤として使用することができる。

Abstract translation: 脱发的原因还没有完全清楚，但在许多方面仍然是未知数。 然而，看起来脱发部分是由头皮中的雄激素激素通过5α-还原酶激活DHT激素而变得活跃的机制，因而丧失了发根中细胞的活性。 在本发明中，通过将以5α还原酶或DHT作为抗原的雌性鸟类接种得到的抗体给予头皮，使DHT的活性被抑制，发根中细胞的活性升高 。 该抗体可以与其它组分一起以组合物的形式使用，例如与另一种毛发生长促进剂一起作为头发补品。

公开(公告)号：WO2013009843A1

公开(公告)日：2013-01-17

申请号：PCT/US2012/046215

申请日：2012-07-11

Applicant: CAMAS INCORPORATED ,  MITTENESS, Bradley M. ,  PHILLIPS, Connie

Inventor： MITTENESS, Bradley M. ,  PHILLIPS, Connie

IPC: A61K39/40 ,  C07K16/02 ,  C07K14/195 ,  C07K16/12

CPC classification number: C07K16/1214 ,  C07K16/1228 ,  C07K16/1232 ,  C07K16/1282 ,  C07K2317/11

Abstract: Anti-toxin compositions are described that include avian antibodies against bacterial toxins. Administration of the anti-toxin compositions binds and neutralizes the bacterial toxin in the animals. Methods of making the anti-toxin compositions against the bacterial toxins are also described. The anti-toxin compositions can be effective against pathogenic bacteria and also to decrease the amount of bacterial toxins in the individual, especially in the GI tract. The anti-toxin compositions can also act as anti-inflammatory agents.

Abstract translation: 描述了抗毒素组合物，其包括针对细菌毒素的禽类抗体。 抗毒素组合物的给药结合并中和动物中的细菌毒素。 还描述了制备针对细菌毒素的抗毒素组合物的方法。 抗毒素组合物可以有效抵抗致病细菌，并且还可减少个体中特别是胃肠道中的细菌毒素的量。 抗毒素组合物也可以作为抗炎剂。

公开(公告)号：WO2007149287A3

公开(公告)日：2008-10-02

申请号：PCT/US2007013903

申请日：2007-06-14

Applicant: RAMAEKERS NUTRITION LLC ,  RAMAEKERS JOSEPH C

Inventor： RAMAEKERS JOSEPH C

IPC: A61K39/395 ,  A61K35/14 ,  A61K35/20 ,  A61K35/54 ,  A61K38/16 ,  A61K38/17 ,  C07K14/00 ,  C07K16/00 ,  C07K16/02 ,  C07K16/04

CPC classification number: C07K16/06 ,  A61K2039/505

Abstract: Compositions are provided comprising transfer factor alone or combined with an antibody. The antibody may be contained in an antibody fraction. The transfer factor and/or the antibody or antibody fraction may be lyophilized. Also provided are formulations further comprising glucans, as well as additional optional components. Also provided are methods for making the compositions and formulations, as well as kits containing the compositions. Methods of preventing and/or treating a condition in a subject using the compositions and/or formulations are also provided. Such conditions may include malignant and benign tumors.

Abstract translation: 提供组合物，其包含单独的转移因子或与抗体组合。 抗体可以包含在抗体部分中。 转移因子和/或抗体或抗体部分可以被冻干。 还提供了进一步包含葡聚糖的制剂，以及另外的任选组分。 还提供了制备组合物和制剂的方法，以及含有组合物的试剂盒。 还提供了使用组合物和/或制剂预防和/或治疗受试者的病症的方法。 这些病症可能包括恶性和良性肿瘤。

公开(公告)号：WO2008051980A3

公开(公告)日：2008-06-19

申请号：PCT/US2007082247

申请日：2007-10-23

Applicant: WISCONSIN ALUMNI RES FOUND ,  AOVATECHNOLOGIES INC ,  COOK MARK ,  PETKOVICH MARTIN ,  HELVIG CHRISTIAN ,  HELLESTAD ERICA ,  CRAWFORD KEITH

Inventor： COOK MARK ,  PETKOVICH MARTIN ,  HELVIG CHRISTIAN ,  HELLESTAD ERICA ,  CRAWFORD KEITH

IPC: A61K39/395 ,  A61P13/12 ,  C07K16/02

CPC classification number: C07K16/28 ,  A61K2039/505 ,  A61K2039/542 ,  C07K2317/34 ,  C07K2317/76

Abstract: A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administering orally to the subject an anti-intestinal sodium phosphate cotransporter type 2B (Npt2B) antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.

Abstract translation: 公开了一种在发生或发展为高磷酸血症风险的人或非人类动物受试者中减少磷酸盐吸收的方法。 该方法包括以有效降低或维持受试者血清磷酸盐浓度的量向对象口服给予抗肠磷酸钠协同转运蛋白2B型（Npt2B）抗体的步骤。

公开(公告)号：WO2008051980A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/082247

申请日：2007-10-23

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  AOVATECHNOLOGIES, INC. ,  COOK, Mark ,  PETKOVICH, Martin ,  HELVIG, Christian ,  HELLESTAD, Erica ,  CRAWFORD, Keith

Inventor： COOK, Mark ,  PETKOVICH, Martin ,  HELVIG, Christian ,  HELLESTAD, Erica ,  CRAWFORD, Keith

IPC: A61K39/395 ,  A61P13/12 ,  C07K16/02

CPC classification number: C07K16/28 ,  A61K2039/505 ,  A61K2039/542 ,  C07K2317/34 ,  C07K2317/76

Abstract: A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administering orally to the subject an anti-intestinal sodium phosphate cotransporter type 2B (Npt2B) antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.

Abstract translation: 公开了一种减少处于发展中或已经发展为高磷酸盐血症风险的人类或非人类动物受试者中磷酸盐吸收的方法。 该方法包括以有效降低或维持受试者血清磷酸盐浓度的量向受试者口服施用抗肠磷酸钠协同转运蛋白2B（Npt2B）抗体的步骤。

公开(公告)号：WO2004026427A3

公开(公告)日：2004-10-07

申请号：PCT/US0328543

申请日：2003-09-11

Applicant: GTC BIOTHERAPEUTICS INC ,  BIRCK-WILSON ESZTER ,  DAY MARIA

Inventor： BIRCK-WILSON ESZTER ,  DAY MARIA

IPC: A61K39/395 ,  B01D20060101 ,  C07K16/02 ,  C07K16/04 ,  C07K16/06 ,  C07K16/18 ,  C12P21/08 ,  G01N33/53 ,  G01N33/531 ,  G01N33/563

CPC classification number: C07K16/04 ,  C07K2317/50

Abstract: The current invention features methods for reliably and controllably separating immunoglobulin half antibodies from immunoglobulin whole antibodies, as well as purified immunoglobulin half antibody preparations and purified immunoglobulin whole antibody preparations while preserving biological activity. These dissociated half antibodies can be chromatographically separated from whole antibodies. There are four known subclasses of IgG molecules: IgG1; IgG2; IgG3; and IgG4. IgG4 molecules differ from the other IgG isotypes in that the disulfide bonds that link the two heavy chain subunits together do not always form. Due to the non-covalent interactions that hold the heavy chain subunits together, the heterogeneity of IgG4 molecules is not apparent following gel filtration of purified IgG4 protein. However, when purified IgG4 protein is separated by denaturing polyacrylamide gel electrophoresis (SDS-PAGE) under non-reducing conditions, two distinct protein species can be identified - whole antibody and "half-antibodies".

Abstract translation: 本发明的特征在于保护生物活性，可靠和可控地将免疫球蛋白半抗体与免疫球蛋白全抗体以及纯化的免疫球蛋白半抗体制剂和纯化的免疫球蛋白全抗体制剂分离。 这些解离的半抗体可以与全部抗体进行色谱分离。 IgG分子有四个已知亚类：IgG1; IgG2的; IgG3; 和IgG4。 IgG4分子与其他IgG同种型不同，因为将两个重链亚基连接在一起的二硫键不总是形成。 由于将重链亚基保持在一起的非共价相互作用，IgG4分子的不均匀性在纯化的IgG4蛋白的凝胶过滤之后不明显。 然而，当在非还原条件下通过变性聚丙烯酰胺凝胶电泳（SDS-PAGE）分离纯化的IgG4蛋白时，可以鉴定出两种不同的蛋白质种类 - 全抗体和“半抗体”。