Invention Application
WO2016156478A1 T CELL RECEPTORS AND PEPTIDES DERIVED BY MUTATIONS FOR THE TREATMENT OF CANCER
审中-公开
T细胞受体和由肿瘤治疗的突变体衍生的肽
- Patent Title: T CELL RECEPTORS AND PEPTIDES DERIVED BY MUTATIONS FOR THE TREATMENT OF CANCER
- Patent Title (中): T细胞受体和由肿瘤治疗的突变体衍生的肽
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Application No.: PCT/EP2016/057038Application Date: 2016-03-31
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Publication No.: WO2016156478A1Publication Date: 2016-10-06
- Inventor: GERHARD, Markus , BUSCH, Dirk , DOESSINGER, Georg , SCHUMACHER, Antonius , LINNEMANN, Carsten
- Applicant: TECHNISCHE UNIVERSITAET MUENCHEN , THE NETHERLANDS CANCER INSTITUTE
- Applicant Address: Arcisstr. 21 80333 Munich DE
- Assignee: TECHNISCHE UNIVERSITAET MUENCHEN,THE NETHERLANDS CANCER INSTITUTE
- Current Assignee: TECHNISCHE UNIVERSITAET MUENCHEN,THE NETHERLANDS CANCER INSTITUTE
- Current Assignee Address: Arcisstr. 21 80333 Munich DE
- Agency: SCHIWECK, Wolfram et al.
- Priority: EP15162015.0 20150331
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; C07K14/045 ; C07K14/47 ; C12N5/0783
Abstract:
The present invention relates to a method for providing a neopeptide-specific T cell, wherein the neopeptide-specific T cell forms a complex having a half-life (T 1/2 ) of at least 50 s with a neopeptide-MHC monomer. The present invention further relates to a T cell obtainable by the method as well as a pharmaceutical composition comprising such T cells.
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