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    MUTEINS OF A1M LIPOCALIN AND METHOD OF PRODUCTION THEREFOR
    1.
    发明申请
    MUTEINS OF A1M LIPOCALIN AND METHOD OF PRODUCTION THEREFOR 审中-公开
    A1M LIPOCALIN的制剂及其生产方法

    公开(公告)号：WO2013113851A1

    公开(公告)日：2013-08-08

    申请号：PCT/EP2013/051962

    申请日：2013-01-31

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： SKERRA, Arne ,  MEINING, Winfried ,  EGGENSTEIN, Evelyn

    IPC: C07K14/47

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/8114 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C40B40/10

    Abstract: The present disclosure relates to a collection of novel muteins derived from human α1m (or a1m) polypeptide or a functional homologue thereof. The disclosure further refers to a α1m mutein capable of specifically binding to one or more targets other than a target to which wild-type α1m binds. The disclosure also relates to a method for producing such collection of muteins and a method for isolating a mutein capable of binding one or more such non-natural targets of wild-type α1m polypeptide. These aspects are made possible due to, e.g, the structural elucidation of α1m disclosed herein by the present inventors, an appreciation of ligand-binding sights thereof and, hence, an understanding of which amino acid positions are most suitable for mutagenesis for re-engineering specificity and affinity for any given target while maintaining the secondary and/or tertiary structure of a1m.

    Abstract translation: 本公开涉及衍生自人α1m（或a1m）多肽或其功能同系物的新型突变蛋白的集合。 本公开还涉及能够特异性结合野生型α1m结合的靶以外的一种或多种目标的α1突变蛋白。 本公开还涉及用于产生这种突变蛋白的收集的方法和分离能够结合野生型α1m多肽的一种或多种这种非天然靶标的突变蛋白的方法。 这些方面由于例如本发明人在此公开的α1m的结构阐释，配体结合瞄准物的鉴定以及因此理解哪种氨基酸位置最适于诱变用于重新设计而成为可能 特异性和亲和力，同时维持a1m的二级和/或三级结构。

    USE OF REDOX MEDIATORS AS ADDITIVES IN ELECTROLYTES OF LITHIUM SULFUR BATTERIES
    4.
    发明申请
    USE OF REDOX MEDIATORS AS ADDITIVES IN ELECTROLYTES OF LITHIUM SULFUR BATTERIES 审中-公开
    使用氧化还原剂作为锂电池电解质中的添加剂

    公开(公告)号：WO2015044829A1

    公开(公告)日：2015-04-02

    申请号：PCT/IB2014/064515

    申请日：2014-09-15

    Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED ,  TECHNISCHE UNIVERSITAET MUENCHEN (TUM)

    Inventor： GARSUCH, Arnd ,  AURBACH, Doron ,  ELAZARI, Ran ,  SALITRA, Gregory ,  MEINI, Stefano

    IPC: H01M10/36 ,  H01M4/58

    CPC classification number: H01M4/5815 ,  H01M4/485 ,  H01M10/052 ,  H01M10/0567 ,  H01M10/0568 ,  H01M10/4235 ,  H01M10/44 ,  Y02T10/7011

    Abstract: The present invention relates to a rechargeable electrochemical cell comprising at least one cathode (A) comprising at least one electroactive sulfur-containing material, at least one anode (B), and at least one electrolyte composition (C) comprising at least one aprotic organic solvent (c1), at least one alkali metal salt (c2), and at least one redox mediator (c3). The present invention further relates to an alkali metal ion battery comprising at least one re- chargeable electrochemical cell as described above and to a device comprising at least one rechargeable electrochemical cell as described above. The present invention further relates to a process for charging for the first time a newly manufactured rechargeable electrochemical cell initially comprising at least one cathode (A) comprising at least one electroactive sulfur- containing material comprising at least one Li-S-group, at least one anode (B), and at least one electrolyte composition (C) comprising at least one aprotic organic solvent (c1), at least one alkali metal salt (c2), and at least one redox mediator (c3).

    Abstract translation: 本发明涉及一种可再充电电化学电池，其包含至少一个包含至少一种电活性含硫材料的阴极（A），至少一种阳极（B）和至少一种包含至少一种非质子有机物 溶剂（c1），至少一种碱金属盐（c2）和至少一种氧化还原介体（c3）。 本发明还涉及包含如上所述的至少一个可再充电电化学电池和包括如上所述的至少一个可充电电化学电池的器件的碱金属离子电池。 本发明还涉及一种首次充电的新制造的可再充电电化学电池的方法，其最初包括至少一个阴极（A），其至少包含至少一种包含至少一个Li-S基的电活性含硫材料，至少 一个阳极（B）和至少一个包含至少一种非质子有机溶剂（c1），至少一种碱金属盐（c2）和至少一种氧化还原介体（c3）的电解质组合物（C）。

    PRODUCTION OF RECOMBINANT COLLAGEN LIKE PROTEINS
    6.
    发明申请
    PRODUCTION OF RECOMBINANT COLLAGEN LIKE PROTEINS 审中-公开
    重组胶原蛋白的生产

    公开(公告)号：WO2007057207A1

    公开(公告)日：2007-05-24

    申请号：PCT/EP2006/011061

    申请日：2006-11-17

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN ,  SCHEIBEL, Thomas

    Inventor： SCHEIBEL, Thomas

    IPC: C07K14/435

    CPC classification number: C07K14/43504

    Abstract: The present invention is directed to a yeast cell for producing a recombinant collagen like protein. The present invention is further directed to a kit of parts or a co-expression system for use in the production of such a protein and to a method of producing said recombinant protein and a thread made therefrom. Furthermore, the invention pertains to proteins or threads obtainable by these methods as well as their use in various fields of technology and medicine.

    Abstract translation: 本发明涉及用于生产重组胶原样蛋白质的酵母细胞。 本发明还涉及一种用于生产这种蛋白质的部分试剂盒或共表达系统以及由其制备的所述重组蛋白质的方法和生产所述重组蛋白质的方法。 此外，本发明涉及可通过这些方法获得的蛋白质或丝线，以及它们在各种技术和医学领域中的应用。

    NIPA POLYPEPTIDES AND USE THEREOF
    7.
    发明申请
    NIPA POLYPEPTIDES AND USE THEREOF 审中-公开
    NIPA多聚物及其用途

    公开(公告)号：WO2004037858A2

    公开(公告)日：2004-05-06

    申请号：PCT/EP2003/011861

    申请日：2003-10-24

    Applicant: TECHNISCHE UNIVERSITAET MUENCHEN ,  DUYSTER, Justus ,  PESCHEL, Christian ,  BAI, Renyunan

    Inventor： DUYSTER, Justus ,  PESCHEL, Christian ,  BAI, Renyunan

    IPC: C07K14/47

    CPC classification number: C07K14/4702 ,  A61K38/00 ,  Y02A50/473

    Abstract: The present invention is directed to interaction partners of ALK fusion proteins and to nucleic acids encoding same. It is further directed to nucleic acids, which selectively hybridize to transcriptional products of those nucleic acids as well as to a molecule, which specifically binds to an interaction partner of this invention. The invention is further related to compositions containing the aforementioned ingredients as well as to their use in the diagnosis and therapy of cancer, degenerative and proliferative disorders.

    Abstract translation: 本发明涉及ALK融合蛋白的相互作用配偶体和编码其的核酸。 进一步涉及核酸，其与那些核酸的转录产物以及特异性结合本发明的相互作用配偶体的分子选择性杂交。 本发明进一步涉及含有上述成分的组合物，以及它们在诊断和治疗癌症，退行性和增殖性疾病中的用途。

    LATENT VARIABLE DECORRELATION
    8.
    发明申请
    LATENT VARIABLE DECORRELATION 审中-公开

    公开(公告)号：WO2022028687A1

    公开(公告)日：2022-02-10

    申请号：PCT/EP2020/072019

    申请日：2020-08-05

    Applicant: NOKIA SOLUTIONS AND NETWORKS OY ,  TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： KAJÓ, Márton ,  ALI-TOLPPA, Janne Tapio ,  MWANJE, Stephen

    IPC: G06N3/04 ,  G06N3/08 ,  G06N7/00 ,  G06N20/00 ,  H04L12/24 ,  G06N3/0454 ,  G06N3/084 ,  G06N3/088 ,  G06N7/005 ,  H04L41/142 ,  H04L41/16 ,  H04L41/5009 ,  H04L43/08

    Abstract: A method for a neural network comprising an input layer, an output layer and one or more intermediate layers is described. The neural network is arranged to generate an output vector of data values at the output layer corresponding to a learned representation of an input vector of data values that is input to the neural network. The method comprises accessing a set of data variables that are determined according to respective entries of output vectors, the output vectors generated on the basis of the evaluation of the neural network on input vectors of data values selected from a training dataset of input vectors, evaluating a predictive model over the set of data variables to determine a subset of data variables and modifying the predictive model and the neural network on the basis of the evaluation whereby the evaluation of the subset of data variables for subsequent input vectors of data values that are input to the neural network generate output vectors of data values that are grouped, according to a measure of similarity, into at least two substantially disjoint subsets.

    A METHOD AND AN APPARATUS FOR FAULT PREDICTION IN NETWORK MANAGEMENT
    9.
    发明申请
    A METHOD AND AN APPARATUS FOR FAULT PREDICTION IN NETWORK MANAGEMENT 审中-公开

    公开(公告)号：WO2020108747A1

    公开(公告)日：2020-06-04

    申请号：PCT/EP2018/082814

    申请日：2018-11-28

    Applicant: NOKIA SOLUTIONS AND NETWORKS OY ,  TECHNISCHE UNIVERSITAET MUENCHEN

    Inventor： SCHULTZ, Benedek ,  ALI-TOLPPA, Janne Tapio ,  KAJÓ, Márton

    IPC: H04W24/02 ,  H04L12/24

    Abstract: Network management apparatus and methods are described. A network management apparatus comprises network data receiving means for receiving network data that is representative of the current condition of a communications network, the network data comprising a plurality of values indicative of the performance of network elements; network data transformation means for transforming the received network data into a network state vector that is indicative of a current state of the network; and network state prediction means for predicting a future network state vector of the network from the current network state vector, the network state prediction means comprising a self- learning prediction module having a memory for storing at least one internal state.

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