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公开(公告)号：WO2023083900A1
公开(公告)日：2023-05-19
申请号：PCT/EP2022/081345
申请日：2022-11-09
发明人： HACKENBERGER, Christian , OCHTROP, Philipp , JAHZERAH, Jahaziel , MACHUI, Paul , SCHUMACHER, Dominik , HELMA-SMETS, Jonas , MAI, Isabelle , KASPER, Marc-André
IPC分类号： A61K47/68
摘要： The present invention relates to a conjugate having the formula (I): wherein a receptor binding molecule (RBM) is connected with a drug moiety (D). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.
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2.发明申请
公开(公告)号：WO2022200478A1
公开(公告)日：2022-09-29
申请号：PCT/EP2022/057721
申请日：2022-03-24
发明人： JAQUIN, Thomas , BEL AIBA, Rachida , ZETTL, Markus , OLWILL, Shane , WALKER, Luke , HEINIG, Kristina
IPC分类号： A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28 , C07K16/32 , A61K39/39558 , C07K16/2878 , C07K2317/24 , C07K2317/31
摘要： The disclosure provides methods and compositions for treating tumors, particularly HER2- expressing tumors, including tumors characterized by a low expression of HER2 and HER2- positive (HER2+) tumors. The method comprises administering a HER2/4-1BB-bispecific agent and a HER2-targeted tyrosine kinase inhibitor (TKI). The disclosure further provides combinations and kits of parts comprising a HER2/4-1 BB-bispecific agent and a HER2-targeted TKI.
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公开(公告)号：WO2022200412A2
公开(公告)日：2022-09-29
申请号：PCT/EP2022/057606
申请日：2022-03-23
发明人： ZETTL, Markus , MORALES KASTRESANA, Aizea , WURZENBERGER, Cornelia , OLWILL, Shane , AVIANO, Kayti
摘要： The disclosure provides methods and compositions for treating tumors, particularly HER2-expressing tumors. The method comprises administering a therapeutically effective amount of a HER2/4-1BB bispecific fusion protein. The HER2/4-1BB bispecific fusion protein may be administered at a first dose and, subsequently, at a second dose, wherein the first dose exceeds the second dose.
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公开(公告)号：WO2022167497A1
公开(公告)日：2022-08-11
申请号：PCT/EP2022/052508
申请日：2022-02-02
申请人： ACM BIOLABS PTE LTD
发明人： NALLANI, Madhavan , LAM, Jian Hang , CORNELL, Thomas Andrew , KHAN, Amit Kumar , MARTIN, Liam Thomas
摘要： The present invention relates to eliciting an immune response in a subject by sole administration of an adjuvant, wherein the adjuvant is associated with a population of polymersomes.
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公开(公告)号：WO2022117729A1
公开(公告)日：2022-06-09
申请号：PCT/EP2021/083972
申请日：2021-12-02
发明人： WONG, Tuck Seng , TEE, Kang Lan , LANGWALLNER, Margit , NALLANI, Madhavan , LANGWALLNER, Christoph
摘要： The present invention refers to a method of producing globin polypeptide recombinantly and a method of producing globin polypeptide with a cell-free translation system. Further, the present invention provides a food product, preferably a meat substitute food product. The present invention is also directed to a vector and a system for recombinant globin polypeptide production as well as to a cell comprising a recombinant expression vector or one or more recombinant nucleic acid molecule(s).
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公开(公告)号：WO2022043490A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073729
申请日：2021-08-27
IPC分类号： A61K31/337 , A61K31/454 , A61K31/55 , A61K31/609 , A61K45/06 , A61P35/00
摘要： The present invention relates to a kit-of-parts comprising at least one mitochondrial uncoupler and at least one cationic amphiphilic drug and its use in medicine. The invention further relates to a pharmaceutical composition comprising at least one mitochondrial uncoupler and at least one cationic amphiphilic drug for use in medicine. Moreover, the invention is directed to the kit-of-parts and the pharmaceutical composition for use in the treatment of cancer, in particular glioma, pancreatic cancer, small cell lung cancer, metastatic prostate cancer, liver cancer and triple-negative breast cancer.
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公开(公告)号：WO2021245240A1
公开(公告)日：2021-12-09
申请号：PCT/EP2021/065020
申请日：2021-06-04
发明人： PEPER-GABRIEL, Janet , PRASSLER, Josef , EICHNER, Timo , GRUENER, Stefan , MOUSA, Ahmed , OLWILL, Shane
IPC分类号： C07K14/705 , C12N5/10 , C07K14/70596
摘要： The disclosure provides multimeric proteins comprising three, four, or more monomer polypeptides, each comprising a first 4-1BB-targeting moiety, an oligomerization moiety, and optionally a linker. The monomer polypeptide may further comprise one or more additional targeting moieties. The oligomerization moiety promotes the trimerization, tetramerization, or higher state of oligomerization of the monomer polypeptides. Such multimeric proteins can be used in many pharmaceutical applications, for example, as anti-cancer agents and/or immune modulators. The present disclosure also concerns methods of making the multimeric proteins described herein as well as compositions comprising such multimeric proteins. The present disclosure further relates to nucleic acid molecules encoding such multimeric proteins and methods for the generation of such multimeric proteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of such multimeric proteins as well as compositions comprising one or more of such multimeric proteins.
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公开(公告)号：WO2021209493A2
公开(公告)日：2021-10-21
申请号：PCT/EP2021/059643
申请日：2021-04-14
申请人： SOLYPLUS GMBH , LEOPOLD GMBH
IPC分类号： A61K31/722 , A61K31/522 , A61K31/7004 , A61K31/728 , A61P31/12 , A61P33/00 , A23L33/00 , A61K9/00 , A61K9/68 , A61Q19/00 , C11D1/00 , A23G4/06 , A23L2/52 , A23L29/275 , A61K8/0241 , A61K8/736 , A61K9/0014 , A61K9/0043 , A61K9/0058 , A61K9/006 , A61K9/0095 , A61Q11/00 , C11D3/221 , C11D3/227 , C11D3/32 , C11D3/48
摘要： The present invention relates to a composition for use in preventing an infection, or treating an infection, or treating a disease caused by an infection, the composition comprising a compound selected from the group consisting of chitosan or a salt thereof, galactose, mannose, caffeine, and any combination thereof.
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9.发明申请
公开(公告)号：WO2021028523A1
公开(公告)日：2021-02-18
申请号：PCT/EP2020/072724
申请日：2020-08-13
IPC分类号： C12N5/071
摘要： Method for assessing the suitability of a sperm for fertilization of an oocyte based on longitudinal axis rotation In various embodiments a method for assessing the suitability of a sperm for fertilization of an oocyte is provided, the method comprising measuring the rotation of at least one sperm in a sperm sample around its longitudinal axis, the sperm being obtained from a male subject, wherein observing no rotation of the sperm is indicative that the sperm is not suitable for fertilization of an oocyte; whereas observing rotation indicates that the sperm may be suitable for fertilization.
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公开(公告)号：WO2021019102A2
公开(公告)日：2021-02-04
申请号：PCT/EP2020/071809
申请日：2020-08-03
申请人： ACM BIOLABS PTE LTD
IPC分类号： A61K39/00 , A61K39/12 , A61K39/385 , A61K39/39 , A61K31/74 , A61K2039/5152 , A61K2039/6093 , A61K39/0005 , A61K39/0011 , A61K9/0019 , A61K9/1273 , C12N2760/16034 , C12N2770/20034
摘要： The present invention relates to a method of eliciting an immune response in a subject by administration of an antigen and an adjuvant, wherein the antigen is associated with a first population of polymersomes, and wherein the adjuvant is associated with a second population of polymersomes, and wherein the two populations of polymersomes are administered to the subject. The present invention also relates to compositions such as vaccines comprising the two polymersome populations of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.
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