发明申请
WO2018011376A1 PYRIMIDINONE DERIVATIVES AND USES THEREOF TO NEUTRALIZE THE BIOLOGICAL ACTIVITY OF CHEMOKINES
审中-公开
嘧啶酮衍生物及其用于中和生物活性的生物活性的用途
- 专利标题： PYRIMIDINONE DERIVATIVES AND USES THEREOF TO NEUTRALIZE THE BIOLOGICAL ACTIVITY OF CHEMOKINES
- 专利标题（中）： 嘧啶酮衍生物及其用于中和生物活性的生物活性的用途
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申请号： PCT/EP2017/067775申请日： 2017-07-13
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公开(公告)号： WO2018011376A1公开(公告)日： 2018-01-18
- 发明人: BONNET, Dominique , FROSSARD, Nelly , GALZI, Jean-Luc , GUIGNABERT, Christophe , HIBERT, Marcel , SIMONIN, Frédéric , MULLER, Sylviane
- 申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE STRASBOURG , UNIVERSITE PARIS-SUD , CENTRE INTERNATIONAL DE
- 申请人地址： 3, rue Michel Ange 75016 PARIS FR
- 专利权人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -,INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ DE STRASBOURG,UNIVERSITE PARIS-SUD,CENTRE INTERNATIONAL DE
- 当前专利权人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -,INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ DE STRASBOURG,UNIVERSITE PARIS-SUD,CENTRE INTERNATIONAL DE
- 当前专利权人地址： 3, rue Michel Ange 75016 PARIS FR
- 代理机构： CABINET PLASSERAUD
- 优先权： EP16305908.2 20160713
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D403/04 ; C07D403/10 ; C07D405/04 ; C07D239/36 ; C07D409/04 ; C07D413/04 ; C07D413/10 ; C07D417/04 ; A61K31/513 ; A61P35/00
摘要：
A subject of the present invention is a compound having the general formula (I) a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B 3 , B 4 , B 5 , Y, X, B 1 and B 2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.
