发明申请
WO2018015525A1 6-HYDROXY-3-[3-HYDROXY-3-METHYL-PENTA-1,4-DIENYL]-2,4,4-TRIMETHYL-CYCLOHEXA-2,5-DIEN-1-ONE
审中-公开
6-羟基-3- [3-羟基-3-甲基 - 戊-1,4-二烯基] -2,4,4-三甲基 - 环己-2,5-二烯-1-酮
- 专利标题： 6-HYDROXY-3-[3-HYDROXY-3-METHYL-PENTA-1,4-DIENYL]-2,4,4-TRIMETHYL-CYCLOHEXA-2,5-DIEN-1-ONE
- 专利标题（中）： 6-羟基-3- [3-羟基-3-甲基 - 戊-1,4-二烯基] -2,4,4-三甲基 - 环己-2,5-二烯-1-酮
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申请号： PCT/EP2017/068452申请日： 2017-07-21
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公开(公告)号： WO2018015525A1公开(公告)日： 2018-01-25
- 发明人: SCHAEFER, Bernd , SIEGEL, Wolfgang
- 申请人： BASF SE
- 申请人地址： Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein DE
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein DE
- 代理机构： REITSTÖTTER - KINZEBACH
- 优先权： EP16180851.4 20160722
- 主分类号： C07C403/08
- IPC分类号： C07C403/08
摘要：
The present invention relates to a process for preparing 6-hydroxy-3-[3-hydroxy-3- methyl-penta-1,4-dienyl]-2,4,4-trimethyl-cyclohexa-2,5-dien-1 -one of the formula (I). The invention also relates to 6-hydroxy-3-[3-hydroxy-3-methyl-penta-1,4-dienyl]-2,4,4- trimethyl-cyclohexa-2,5-dien-1 -one having a high E/Z-ratio of at least 80:20 and to the use thereof as a starting material for the preparation of astaxanthin or astacene. (l), (ll) The process comprises the reaction of the compound of formula (II), namely 6-hydroxy- 3-(3-hydroxy-3-methyl-pent-4-en-1 -ynyl)-2,4,4-trimethyl-cyclohex-2-en-1 -one, with a base. In this process, 1 E-isomer is formed with high selectivity, resulting in the compound of formula (I) with a E/Z-ratio of at least 80:20, in particular at least 90:10.
