发明申请
- 专利标题: MIF INHIBITORS AND METHODS OF USE THEREOF
- 专利标题(中): MIF抑制剂及其使用方法
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申请号: PCT/US2017/049778申请日: 2017-08-31
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公开(公告)号: WO2018045250A1公开(公告)日: 2018-03-08
- 发明人: DAWSON, Ted M. , DAWSON, Valina L. , WANG, Yingfei , PARK, Hyejin , LIU, Jun , PENG, Hanjing
- 申请人: THE JOHNS HOPKINS UNIVERSITY
- 申请人地址: 3400 N. Charles Street Baltimore, MD 21218 US
- 专利权人: THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人: THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址: 3400 N. Charles Street Baltimore, MD 21218 US
- 代理机构: HAILE, Lisa A. et al.
- 优先权: US62/383,209 20160902
- 主分类号: A61P25/00
- IPC分类号: A61P25/00 ; A61P25/28 ; A61K38/17
摘要:
Provided herein are methods of treating a disease, such as Parkinson's disease, that is due to increased poly [ADP-ribose] polymerase 1 (PARP-1) activation, by inhibiting macrophage migration inhibitory factor (MIF) nuclease activity.