公开(公告)号：WO2021071931A1

公开(公告)日：2021-04-15

申请号：PCT/US2020/054555

申请日：2020-10-07

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： LIU, Jun, O. ,  CHENG, Zhiqiang ,  ZHU, Heng ,  GUO, Zufeng ,  PENG, Hanjing

IPC分类号： A61K31/4353 ,  A61K31/436 ,  A61K47/56 ,  A61P35/00

摘要： Surface structures that enable the preparation of three-dimensional microarrays of proteins or small molecules or other types of macromolecules are disclosed. The three-dimensional microarrays possess higher sensitivity for detecting protein-macromolecule and small molecule-protein interactions in a high-throughput fashion.

公开(公告)号：WO2021067405A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053486

申请日：2020-09-30

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： DAWSON, Ted, M. ,  DAWSON, Valina, L. ,  LIU, Jun ,  PARK, Hyejin ,  KAM, Tae-In ,  PENG, Hanjing ,  AYINAMPUDI, Venkata, Subbarao

IPC分类号： C07D498/04 ,  C07D498/14 ,  C07F9/32

摘要： The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

公开(公告)号：WO2020154455A1

公开(公告)日：2020-07-30

申请号：PCT/US2020/014699

申请日：2020-01-23

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： LIU, Jun O. ,  SUN, Zhaoli ,  PEIFFER, Brandon J. ,  WANG, Yuefan ,  QI, Le ,  GUO, Zufeng ,  PENG, Hanjing ,  AHMADI, Ali

IPC分类号： C07D498/18 ,  C07H19/01 ,  A61K31/435 ,  A61K31/706 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00

摘要： The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds.

公开(公告)号：WO2018045250A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/049778

申请日：2017-08-31

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： DAWSON, Ted M. ,  DAWSON, Valina L. ,  WANG, Yingfei ,  PARK, Hyejin ,  LIU, Jun ,  PENG, Hanjing

IPC分类号： A61P25/00 ,  A61P25/28 ,  A61K38/17

摘要： Provided herein are methods of treating a disease, such as Parkinson's disease, that is due to increased poly [ADP-ribose] polymerase 1 (PARP-1) activation, by inhibiting macrophage migration inhibitory factor (MIF) nuclease activity.

摘要翻译： 本文提供了治疗由于增加的聚[ADP-核糖]聚合酶1（PARP-1）激活，通过抑制巨噬细胞迁移抑制因子（MIF）引起的疾病（例如帕金森氏病）的方法 ）核酸酶活性。

公开(公告)号：WO2017136708A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016481

申请日：2017-02-03

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： LIU, Jun ,  WANG, Jingxin ,  GUO, Zufeng ,  HONG, Sam ,  LIU, Wukun ,  PENG, Hanjing ,  DAS, Manisha

IPC分类号： C07K17/08 ,  G01N33/566

CPC分类号： C07K17/08 ,  B82Y5/00 ,  C07K1/047 ,  G01N33/574 ,  G01N2500/00 ,  G01N2800/24

摘要： A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

摘要翻译： 提供含有通式结构（A）和（E）的化合物的拉帕福星文库以及这些化合物的合成。