公开(公告)号：WO2021067405A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053486

申请日：2020-09-30

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted, M. ,  DAWSON, Valina, L. ,  LIU, Jun ,  PARK, Hyejin ,  KAM, Tae-In ,  PENG, Hanjing ,  AYINAMPUDI, Venkata, Subbarao

IPC: C07D498/04 ,  C07D498/14 ,  C07F9/32

Abstract: The present disclosure provides neuroprotective compounds along with their use in treating disease such as Parkinson's disease (PD). The compounds can be used as inhibitors for Parthanatos Associated AIF (apoptosis-inducing factor) Nuclease (PAAN), also known as macrophage migration inhibitor factor (MIF).

公开(公告)号：WO2018045250A1

公开(公告)日：2018-03-08

申请号：PCT/US2017/049778

申请日：2017-08-31

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： DAWSON, Ted M. ,  DAWSON, Valina L. ,  WANG, Yingfei ,  PARK, Hyejin ,  LIU, Jun ,  PENG, Hanjing

IPC: A61P25/00 ,  A61P25/28 ,  A61K38/17

Abstract: Provided herein are methods of treating a disease, such as Parkinson's disease, that is due to increased poly [ADP-ribose] polymerase 1 (PARP-1) activation, by inhibiting macrophage migration inhibitory factor (MIF) nuclease activity.

Abstract translation: 本文提供了治疗由于增加的聚[ADP-核糖]聚合酶1（PARP-1）激活，通过抑制巨噬细胞迁移抑制因子（MIF）引起的疾病（例如帕金森氏病）的方法 ）核酸酶活性。