Invention Application
WO2018065611A1 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE
审中-公开
2-氨基-N-（芳基磺酰基） - 乙酰胺化合物作为细菌氨酰基-TactNA合成酶的抑制剂
- Patent Title: 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE
- Patent Title (中): 2-氨基-N-（芳基磺酰基） - 乙酰胺化合物作为细菌氨酰基-TactNA合成酶的抑制剂
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Application No.: PCT/EP2017/075567Application Date: 2017-10-06
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Publication No.: WO2018065611A1Publication Date: 2018-04-12
- Inventor: FINN, Paul William , CHARLTON, Michael , EDMUND, Grace , JIRGENSONS, Aigars , LOZA, Einars
- Applicant: OXFORD DRUG DESIGN LIMITED
- Applicant Address: The Walbrook Building 25 Walbrook London Greater London EC4N 8AF GB
- Assignee: OXFORD DRUG DESIGN LIMITED
- Current Assignee: OXFORD DRUG DESIGN LIMITED
- Current Assignee Address: The Walbrook Building 25 Walbrook London Greater London EC4N 8AF GB
- Agency: WYTENBURG, Wilhelmus et al.
- Priority: GB1617064.9 20161007
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07D333/34 ; C07D233/54 ; C07D239/38 ; C07D209/04 ; C07D213/16 ; C07D307/64 ; A61K31/34 ; A61K31/381 ; A61K31/404 ; A61K31/4164 ; A61K31/435 ; A61K31/505 ; A61P31/04 ; C07C15/04
Abstract:
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino- N -(arylsulfinyl)- acetamide compounds that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl- tRNA synthetase (aaRS) (e.g., bacterial leucyl-t RNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc .
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