- 专利标题： 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AS IMMUNOSTIMULANTS
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申请号： PCT/US2018/000243申请日： 2018-08-16
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公开(公告)号： WO2019035968A1公开(公告)日： 2019-02-21
- 发明人: POUDEL, Yam, B. , HE, Liqi , GANGWAR, Sanjeev , POSY, Shoshana, L. , SIVAPRAKASAM, Prasanna
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： Route 206 And Province Line Road Princeton, NJ 08543 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： Route 206 And Province Line Road Princeton, NJ 08543 US
- 代理机构： CHAO, Yuan et al.
- 优先权： US62/546,195 20170816
- 主分类号： C07D473/18
- IPC分类号： C07D473/18 ; A61K31/522 ; A61P37/04
摘要：
Compounds having a structure according to formula (I). where R 1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
