-
1.发明申请
公开(公告)号：WO2020028608A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044575
申请日：2019-08-01
发明人： POUDEL, Yam B. , GANGWAR, Sanjeev , HE, Liqi , SIVAPRAKASAM, Prasanna , BROEKEMA, Matthias , CHOWDARI, Naidu S. , COX, Matthew , TARBY, Christine M. , ZHANG, Qian
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
2.发明申请
公开(公告)号：WO2019035968A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/000243
申请日：2018-08-16
IPC分类号： C07D473/18 , A61K31/522 , A61P37/04
摘要： Compounds having a structure according to formula (I). where R 1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
-
公开(公告)号：WO2010042699A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/059968
申请日：2009-10-08
申请人： BRISTOL-MYERS SQUIBB COMPANY , FINK, Brian , CHEN, Libing , GAVAI, Ashvinikumar , HE, Liqi , KIM, Soong-Hoon , NATION, Andrew , ZHAO, Yufen , ZHANG, Litai
发明人： FINK, Brian , CHEN, Libing , GAVAI, Ashvinikumar , HE, Liqi , KIM, Soong-Hoon , NATION, Andrew , ZHAO, Yufen , ZHANG, Litai
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , C07D498/04
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使它们用作抗癌剂。
-
公开(公告)号：WO2021154669A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014983
申请日：2021-01-26
发明人： HE, Liqi , GAVAI, Ashvinikumar V. , GANGWAR, Sanjeev , CONG, Qiang , POUDEL, Yam B. , SIVAPRAKASAM, Prasanna , TARBY, Christine M. , GILL, Patrice , DONNELL, Andrew F. , SUBBAIAH, Murugaiah Andappan Murugaiah
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
公开(公告)号：WO2021154665A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014979
申请日：2021-01-26
发明人： ZHANG, Qian , GANGWAR, Sanjeev , GAVAI, Ashvinikumar V. , CONG, Qiang , POUDEL, Yam B. , HE, Liqi , SIVAPRAKASAM, Prasanna , TARBY, Christine M.
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
公开(公告)号：WO2019209811A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/028697
申请日：2019-04-23
发明人： PURANDARE, Ashok V. , WAN, Honghe , HE, Liqi , GANGWAR, Sanjeev , POSY, Shoshana L. , POUDEL, Yam B. , SIVAPRAKASAM, Prasanna , CHOWDARI, Naidu S.
IPC分类号： C07D487/22 , A61K31/522
摘要： Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.
-
公开(公告)号：WO2021154663A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014977
申请日：2021-01-26
发明人： POUDEL, Yam B. , COX, Matthew , HE, Liqi , O'MALLEY, Daniel , GAVAI, Ashvinikumar V. , GANGWAR, Sanjeev , BROEKEMA, Matthias , SIVAPRAKASAM, Prasanna , TARBY, Christine M. , ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
公开(公告)号：WO2021154662A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014976
申请日：2021-01-26
发明人： COX, Matthew , HE, Liqi , GANGWAR, Sanjeev , GAVAI, Ashvinikumar V. , BROEKEMA, Matthias , CONG, Qiang , O'MALLEY, Daniel , POUDEL, Yam B. , TARBY, Christine M.
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
公开(公告)号：WO2011123493A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030437
申请日：2011-03-30
申请人： BRISTOL-MYERS SQUIBB COMPANY , MARKWALDER, Jay A. , FINK, Brian E. , GAVAI, Ashvinikumar V. , HE, Liqi , KIM, Soong-Hoon , SEITZ, Steven P.
发明人： MARKWALDER, Jay A. , FINK, Brian E. , GAVAI, Ashvinikumar V. , HE, Liqi , KIM, Soong-Hoon , SEITZ, Steven P.
IPC分类号： C07D487/04 , A61P35/00 , A61K31/53
CPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/04 , C07D407/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) pyrrolotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）吡咯并三嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
-
公开(公告)号：WO2021154668A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/014982
申请日：2021-01-26
发明人： POUDEL, Yam B. , COX, Matthew , HE, Liqi , GAVAI, Ashvinikumar V. , GANGWAR, Sanjeev , BROEKEMA, Matthias , TARBY, Christine M. , SUBBAIAH, Murugaiah Andappan Murugaiah
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.018 秒)
