发明申请
- 专利标题： CAR-EXPRESSING IMMUNE CELLS THAT SPECIFICALLY TARGET MESOTHELIN AND USES THEREOF
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申请号： PCT/US2022/038640申请日： 2022-07-28
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公开(公告)号： WO2023009700A2公开(公告)日： 2023-02-02
- 发明人: TAKE, Chihiro , KASSAI, Yoshiaki , HE, Xingyue , KUHN, Chantal
- 申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , SHAPIRO, Gary
- 申请人地址： 1-1, Doshomachi 4-chome; c/o Millennium Pharmaceuticals, Inc.
- 专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED,SHAPIRO, Gary
- 当前专利权人： TAKEDA PHARMACEUTICAL COMPANY LIMITED,SHAPIRO, Gary
- 当前专利权人地址： 1-1, Doshomachi 4-chome; c/o Millennium Pharmaceuticals, Inc.
- 代理机构： MAEBIUS, Stephen et al.
- 优先权： US63/227,115 2021-07-29
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/30 ; C12N15/86 ; A61K2039/5156 ; A61K39/0011 ; A61P35/00 ; C07K14/523 ; C07K14/5443 ; C07K14/7051 ; C07K2317/622 ; C07K2319/03
摘要：
Disclosed herein are engineered immune cells that specifically recognizes mesothelin and expresses IL-15 and optionally CCL19. Also disclosed herein are isolated nucleic acid molecules comprising a polynucleotide encoding a chimeric antigen receptor (CAR) comprising an antibody that specifically recognizes mesothelin, and a 4- IBB intracellular region; and a polynucleotide encoding IL- 15; and optionally a polynucleotide encoding CCL19, vectors, pharmaceutical compositions comprising the nucleic acid molecules, and methods of using the engineered immune cells.
